Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Synthetic, structural and solution speciation studies on binary Al(III)-(carboxy)phosphonate systems. Relevance to the neurotoxic potential of Al(III)
Δημιουργός/Συγγραφέας:	Georgantas, V. Kotsakis, N. Raptopoulou, C. P. Terzis, A. Iordanidis, L. [EL] Ζερβού, Μαρία[EN] Zervou, Maria Jakusch, T. Kiss, T. Salifoglou, A.
Εκδότης:	Elsevier Inc.
Τόπος έκδοσης:	NEW YORK
Ημερομηνία:	2009-11
Γλώσσα:	Αγγλικά
ISSN:	0162-0134
DOI:	10.1016/j.jinorgbio.2009.05.020
Περίληψη:	Efforts to delineate the interactions of neurotoxic Al(III) with low molecular mass substrates relevant to neurodegenerative processes, led to the investigation of the pH-specific synthetic chemistry of the binary Al(III)-[N-(phosphonomethyl) iminodiacetic acid] (Al-NTAP), Al(III)-[nitrilo-tris(methylene-phosphonic acid)] (Al-NTA3P), and Al(III)-[1-hydroxy ethylidene-1,1-diphosphonic acid] (Al-HEDP) systems, in correlation with solution speciation studies. Reaction of Al(NO(3))(3)center dot 9H(2)O with NTAP at pH 7.0 and 4.0 afforded the new species (CH(6)N(3))(4)[Al(2)(C(5)H(6)NPO(7))(2)(OH)(2)]center dot 8H(2)O (1) and (NH(4))(2)[Al(2)(C(5)H(6)NPO(7))(2)(H(2)O)(2)]center dot 4H(2)O (2), while reaction of Al(NO(3))(3)center dot 9H(2)O with NTA3P led to K(8)[Al(2)(C(3)H(6)NP(3)O(9))(2)(OH)(2)]center dot 20H(2)O (3). Complexes 1-3 were characterized by elemental analysis, FT-IR, (13)C, (31)p, (1)H NMR (for 1-2 solid state and solution NMR where feasible), and X-ray crystallography. The structures of 1-3 reveal the presence of uniquely defined dinuclear complexes of octahedral Al(III) bound to fully deprotonated phosphonate ligands, water and hydroxo moieties. The aqueous solution speciation studies on the aforementioned binary systems project a clear picture of the binary Al(III)-(carboxy)phosphonate interactions and species under variable pH-conditions and specific Al(Ill):ligand stoichiometry. The concurrent solid state and solution work (a) exemplifies essential structural and chemical attributes of soluble aqueous species, reflecting well-defined interactions of Al(III) with phosphosubstrates and (b) strengthens the potential linkage of neurotoxic Al(III) chemical reactivity toward O,N-contAlning (carboxy)phosphate-rich cellular targets.
Τίτλος πηγής δημοσίευσης:	Journal of Inorganic Biochemistry (formerly Known as Bioinorganic Chemistry)
Τόμος/Κεφάλαιο:	103
Τεύχος:	11
Σελίδες:	1530-1541
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Χημεία (Γενικά)[EN] Chemistry (General)
Λέξεις-Κλειδιά:	Neurotoxic aluminum Binary aluminum-(carboxy)phosphonate interactions Aqueous structural speciation X-ray crystal structure Solid state-solution property correlation Chemistry, Inorganic & Nuclear
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2009 Elsevier Inc. All rights reserved.
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.elsevier.com/locate/jinorgbio
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Οργανικής και Φαρμακευτικής Χημείας (ΙΟΦΧ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο