Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Aqueous V(V)-Peroxo-Amino Acid Chemistry. Synthesis, Structural and Spectroscopic Characterization of Unusual Ternary Dinuclear Tetraperoxo Vanadium(V)-Glycine Complexes
Δημιουργός/Συγγραφέας:	Gabriel, C. Kaliva, M. Venetis, J. Baran, P. Rodriguez-Escudero, I. Voyiatzis, G. [EL] Ζερβού, Μαρία[EN] Zervou, Maria Salifoglou, A.
Εκδότης:	American Chemical Society
Τόπος έκδοσης:	WASHINGTON
Ημερομηνία:	2009-01-19
Γλώσσα:	Αγγλικά
ISSN:	0020-1669
DOI:	10.1021/ic801427b
Περίληψη:	Vanadium participation in cellular events entails in-depth comprehension of its soluble and bioavailable forms bearing physiological ligands in aqueous distributions of binary and ternary systems. Poised to understand the ternary V(V)-H(2)O(2)-amino acid interactions relevant to that metal ion's biological role, we have launched synthetic efforts involving the physiological ligands glycine and H(2)O(2). In a pH-specific fashion, V(2)O(5), glycine, and H(2)O(2) reacted and afforded the unusual complexes (H(3)O)(2)[V(2)(O)(2)(mu(2):eta(2):eta(1)-O(2))(2)(eta(2)-O(2))(2)(C(2)H(5)NO(2))]center dot 5/4H(2)O (1) and K(2)[V(2)(O)(2)(mu(2):eta(2):eta(1)-O(2))(2)(eta(2)-O(2))(2)(C(2)H(5)NO(2))]center dot H(2)O (2).1 crystallizes in the triclinic space group P (1) over bar, with a = 7.805(4) angstrom, b = 8.134(5) angstrom, c = 12.010(7) angstrom, alpha = 72.298(9)degrees, beta = 72.991(9)degrees, gamma = 64.111(9)degrees, V = 641.9(6) angstrom(3), and Z = 2. 2 crystallizes in the triclinic space group P (1) over bar, with a = 7.6766(9) angstrom, b = 7.9534(9) angstrom, c = 11.7494(13) angstrom, alpha = 71.768(2)degrees, beta = 73.233(2)degrees, gamma = 65.660(2)degrees, V = 610.15(12) angstrom(3), and Z= 2. Both complexes 1 and 2 were characterized by UV/visible, LC-MS, FT-IR, Raman, NMR spectroscopy, cyclic voltammetry, and X-ray crystallography. The structures of 1 and 2 reveal the presence of unusual ternary dinuclear vanadium-tetraperoxo-glycine complexes containing [(V(v)=O)(O(2))(2)](-) units interacting through long V-O bonds and an effective glycinate bridge. The latter ligand is present in the dianionic assembly as a bidentate moiety spanning both V(V) centers in a zwitterionic form. The collective physicochemical properties of the two ternary species 1 and 2 project the chemical role of the low molecular mass biosubstrate glycine in binding V(V)-diperoxo units, thereby stabilizing a dinuclear V(V)-tetraperoxo dianion. Structural comparisons of the anions in 1 and 2 with other known dinuclear V(V)-tetraperoxo binary anionic species provide insight into the chemical reactivity of V(V)-diperoxo species in key cellular events such as insulin mimesis and antitumorigenicity, potentially modulated by the presence of glycinate and hydrogen peroxide.
Τίτλος πηγής δημοσίευσης:	Inorganic Chemistry
Τόμος/Κεφάλαιο:	48
Τεύχος:	2
Σελίδες:	476-487
Θεματική Κατηγορία:	[EL] Χημεία (Γενικά)[EN] Chemistry (General)
Λέξεις-Κλειδιά:	Chemistry, Inorganic & Nuclear
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© AMER CHEMICAL SOC
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://pubs.acs.org/ic
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Οργανικής και Φαρμακευτικής Χημείας (ΙΟΦΧ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο