Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	New cyclodextrin dimers and trimers capable of forming supramolecular adducts with shape-specific ligands
Δημιουργός/Συγγραφέας:	Aime, Silvio Gianolio, Eliana Arena, Francesca Barge, Alessandro Martina, Katia [EL] Χαιρόπουλος, Γεώργιος Α.[EN] Heropoulos, George A. Cravotto, Giancarlo
Εκδότης:	Royal Society Chemistry
Τόπος έκδοσης:	Cambridge
Ημερομηνία:	2009
Γλώσσα:	Αγγλικά
ISSN:	1477-0520
DOI:	10.1039/b812172a
Περίληψη:	Bridged cyclodextrin dimers and trimers, in which respectively two and three hydrophobic cavities lie in close proximity, display much higher binding affinities and molecular selectivities than do parent cyclodextrins (CDs). By joining beta CD units with links inserted at different positions (2-2', 3-2', 6-2' or 6-2'-6 '') and interposing spacers of different lengths and shapes, multicavity structures can be synthesized that are precisely tailored to. t specific guest molecules. This enzyme-mimicking strategy can also be used to generate stable supramolecular adducts. A series of CD dimers and trimers was prepared in good yields by carrying out the critical synthetic steps under power ultrasound (US) or microwave (MW) irradiation. Starting from azide and acetylenic CD derivatives, we exploited an efficient MW-promoted Huisgen 1,3-dipolar cycloaddition in the presence of Cu(I) salts. The resulting bridged CD derivatives gave stable adducts with magnetic-resonance-imaging contrast agents (MRI CAs) containing gadolinium(III) chelates. These inclusion complexes were found to be 2 to 3 orders of magnitude more stable than those formed by beta CD and to be endowed with high relaxivity
Τίτλος πηγής δημοσίευσης:	Organic & Biomolecular Chemistry
Τόμος/Κεφάλαιο:	7
Τεύχος:	2
Σελίδες:	370-379
Θεματική Κατηγορία:	[EL] Οργανική χημεία[EN] Organic chemistry
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© ROYAL SOC CHEMISTRY
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Οργανικής και Φαρμακευτικής Χημείας (ΙΟΦΧ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο