Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Amphiphilic gradient copolymers of 2-methyl- and 2-phenyl-2-oxazoline: self-organization in aqueous media and drug encapsulation
Δημιουργός/Συγγραφέας:	Milonaki, Yanna Kaditi, Eleni [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos, Costas
Εκδότης:	John Wiley & Sons, Inc.
Τόπος έκδοσης:	MALDEN
Ημερομηνία:	2012-03-15
Γλώσσα:	Αγγλικά
ISSN:	0887-624X
DOI:	10.1002/pola.25888
Περίληψη:	Gradient (or pseudo-diblock) copolymers were synthesized from 2-methyl-2-oxazoline and 2-phenyl-2-oxazoline monomer mixtures via cationic polymerization. The self-assembling properties of these biocompatible gradient copolymers in aqueous solutions were investigated, in an effort to use the produced nanostructures as nanocarriers for hydrophobic pharmaceutical molecules. Dynamic and static light scattering as well as AFM measurements showed that the copolymers assemble in different supramolecular nanostructures (spherical micelles, vesicles and aggregates) depending on copolymer composition. Fluorescence spectroscopy studies revealed a microenvironment of unusually high polarity inside the nanostructures. This observation is related partly to the gradient structure of the copolymers. The polymeric nanostructures were stable with time. Their structural properties in different aqueous mediaPBS buffer, RPMI solutionsimulating conditions used in pharmacological/medicinal studies, have been also investigated and a composition dependent behavior was observed. Finally, the hydrophobic drug indomethacin was successfully encapsulated within the gradient copolymer nanostructures and the properties of the mixed aggregates were studied in respect to the initial copolymer assemblies. The produced aggregates encapsulating indomethacin showed a significant increase of their mass and size compared to original purely polymeric ones.
Τίτλος πηγής δημοσίευσης:	Journal of Polymer Science Part A-polymer Chemistry
Τόμος/Κεφάλαιο:	50
Τεύχος:	6
Σελίδες:	1226-1237
Λέξεις-Κλειδιά:	cationic polymerization drug delivery systems gradient copolymers polyoxazolines self-assembly Polymer Science
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www3.interscience.wiley.com/cgi-bin/jhome/36444
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο