Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	New Drug Delivery Nanosystem Combining Liposomal and Dendrimeric Technology (Liposomal Locked-In Dendrimers) for Cancer Therapy
Δημιουργός/Συγγραφέας:	Gardikis, Konstantinos Hatziantoniou, Sophia Bucos, Madalina Fessas, Dimitrios Signorelli, Marco Felekis, Theodoros [EL] Ζερβού, Μαρία[EN] Zervou, Maria [EL] Σκρέττας, Κωνσταντίνος Γ.[EN] Screttas, Constantinos G. [EL] Στηλ, Μπάρυ[EN] Steele, Barry R. Ionov, Maksim [EL] Μίχα-Σκρέττα, Μαρία[EN] Micha-Screttas, Maria Klajnert, Barbara Bryszewska, Maria Demetzos, Costas
Εκδότης:	John Wiley & Sons, Inc.
Τόπος έκδοσης:	MALDEN
Ημερομηνία:	2010-08
Γλώσσα:	Αγγλικά
ISSN:	0022-3549
DOI:	10.1002/jps.22121
Περίληψη:	Liposomal locked-in dendrimers (LLDs), the combination of liposomes and dendrimers in one formulation, represents a relatively new term in the drug carrier technology. LLDs undergone appropriate physicochemical investigation can merge the benefits of liposomal and dendrimeric nanocarriers. In this study generation 1 and 2 hydroxy-terminated dendrimers were synthesized and were then "locked" in liposomes consisting of DOPC/DPPG. The anticancer drug doxorubicin (Dox) was loaded Into pure liposomes or LLDs and the final products were subjected to lyophilization. The loading of Dox as well as its in vitro release rate from all systems was determined and the interaction of liposomes with dendrimers was assessed by thermal analysis and fluorescence spectroscopy The results were very promising in terms of drug encapsulation and release rate, factors that can alter the therapeutic profile of a drug with low therapeutic index such as Dox Physicochemical methods revealed a strong, generation dependent, interaction between liposomes and dendrimers that probably is the basis for the higher loading and slower drug release from the LLDs comparing to pure liposomes. 2010 Wiley-Liss, Inc and the American Pharmacists Association J Pharm Sci 99 3561-3571, 2010
Τίτλος πηγής δημοσίευσης:	Journal of Pharmaceutical Sciences
Τόμος/Κεφάλαιο:	99
Τεύχος:	8
Σελίδες:	3561-3571
Θεματική Κατηγορία:	[EL] Χημεία (Γενικά)[EN] Chemistry (General) [EL] Φαρμακευτική[EN] Pharmacy and materia medica
Λέξεις-Κλειδιά:	liposome dendrimer doxorubicin in vitro release differential scanning calorimetry fluorescence spectroscopy Chemistry, Medicinal Chemistry, Multidisciplinary
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© WILEY-BLACKWELL
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.aapspharmaceutica.com/publications/journal.asp?Journal=j.%20pharm.%20sci
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Οργανικής και Φαρμακευτικής Χημείας (ΙΟΦΧ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο