Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Hypertension study in anaesthetized rabbits: protocol proposal for AT(1) antagonists screening
Δημιουργός/Συγγραφέας:	Politi, Aggeliki P. [EL] Ζερβού, Μαρία[EN] Zervou, Maria Triantafyllidi, Helen [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis [EL] Μαυρομούστακος, Θωμάς[EN] Mavromoustakos, Thomas Zoga, Anastasia A. Moutevelis-Minakakis, Panagiota Kokotos, George Iliodromitis, Efstathios K. Kremastinos, Dimitris Th
Εκδότης:	Sage Publications Limited
Τόπος έκδοσης:	London
Ημερομηνία:	2010-06
Γλώσσα:	Αγγλικά
ISSN:	1470-3203
DOI:	10.1177/1470320310365016
Περίληψη:	Introduction: The aim of this study was to establish an optimized fast and safe protocol for the pharmacological screening of AT(1) antagonists. Materials and methods: The pharmaceutical prototype AT(1) antagonist losartan, its active metabolite EXP3174 and the synthetic compound MMK1 were analysed in order to validate the protocol. Ang II was continuously infused while the animals received the drugs in two procedures. Results: In the post-treatment procedure drugs were administered either in a single bolus dose or in a sequential manner. When losartan was administered in a single bolus dose, efficacy was evident until the 7th min (p=0.012) whilst EXP3174 infusion extended the efficiency up to the end of the study (p=0.006). In addition, the sequential injections of losartan prolonged the inhibitory time interval until the end of the study (p=0.045). In the pre-treatment procedure, results suggested a dose-dependent inhibitory effect for both antagonists. The pressor response to Ang II was unchanged after MMK1 administration either in the post-or in the pre-treatment mode. Conclusions: The proposed protocol appears to be safe, simple and fast for the pharmacological screening of AT1 antagonists and enables the evaluation of new antagonists using lower doses than any other reported in the literature.
Τίτλος πηγής δημοσίευσης:	Journal of the Renin-angiotensin-aldosterone System
Τόμος/Κεφάλαιο:	11
Τεύχος:	2
Σελίδες:	103-110
Λέξεις-Κλειδιά:	animal model AT(1) antagonist EXP3174 hypertension losartan Peripheral Vascular Disease Cardiovascular System & Cardiology
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© SAGE PUBLICATIONS LTD
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://jra.sagepub.com/
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Οργανικής και Φαρμακευτικής Χημείας (ΙΟΦΧ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο