Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	beta-lactam Functionalized Poly(isoprene-b-ethylene oxide) Amphiphilic Block Copolymer Micelles as a New Nanocarrier System for Curcumin
Δημιουργός/Συγγραφέας:	Gardikis, Konstantinos Dimas, Konstantinos Georgopoulos, Aristidis Kaditi, Eleni [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos, Costas
Εκδότης:	Bentham Science Publ Limited
Τόπος έκδοσης:	Sharjah
Ημερομηνία:	2010-06
Γλώσσα:	Αγγλικά
ISSN:	1573-4137
Περίληψη:	Curcumin is a natural compound with biological activities and potent anticancer effects that has the drawback of poor water solubility which leads to low bioavailability. In this work curcumin was formulated in new physicochemically characterized micellar carriers composed of new synthetic block copolymers. The study of the in vitro release rate of curcumin from the formulas, as well as the in vitro activity of free curcumin and of curcumin-loaded into micelles, against a panel of colorectal cancer cell lines was also part of this study. New beta-lactam functionalized poly(isoprene-b-ethylene oxide) amphiphilic block copolymers, were synthesized by the combination of anionic polymerization and selective postpolymerization functionalization of the polyisoprene block with chlorosulfonylisocyanate. Micelles composed of the synthetic copolymers were formulated in order to incorporate curcumin. As the results revealed, increase in the percentage of the lipophilic block of micelles, led to higher encapsulation efficiency and loading capacity while the size was found to be smaller and the in vitro release rate slower. In vitro cytotoxicity results showed similar or slightly higher activity for curcumin-loaded into micelles than free curcumin, a fact that could be attributed to the similar in vitro cellular uptake profiles of curcumin and of curcumin-loaded into micelles.
Τίτλος πηγής δημοσίευσης:	Current Nanoscience
Τόμος/Κεφάλαιο:	6
Τεύχος:	3
Σελίδες:	277-284
Θεματική Κατηγορία:	[EL] Βιοτεχνολογία[EN] Biotechnology [EL] Επιστήμη (Γενικά)[EN] Science (General) [EL] Τεχνολογία (Γενικά)[EN] Technology (General)
Λέξεις-Κλειδιά:	Curcumin block copolymer micelles cytotoxic activity colorectal cancer cell lines Nanoscience & Nanotechnology Materials Science, Multidisciplinary
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© BENTHAM SCIENCE PUBL LTD
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο