Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Design and development of multi-walled carbon nanotube-liposome drug delivery platforms
Δημιουργός/Συγγραφέας:	Pippa, Natassa Chronopoulos, Demetrios D. [EL] Στέλλας, Δημήτρης[EN] Stellas, Dimitris Fernández-Pacheco, Rodrigo Arenal, Raul Demetzos, Costas [EL] Ταγματάρχης, Νίκος[EN] Tagmatarchis, Nikos
Εκδότης:	Elsevier BV
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	0378-5173
DOI:	10.1016/j.ijpharm.2017.06.043
Περίληψη:	The aim of this study is to design and develop delivery platforms made of liposomes and multi-walled carbon nanotubes (MWCNTs). We used different lipids (with different main transition temperature (Tm)) and differently functionalized MWCNTs with organic addends possessing either positive or negative charge. The phospholipids used for the formulations were 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) (Tm=41ºC) and L-α-phosphatidylcholine, hydrogenated (Soy) (HSPC) (Tm=53ºC). By Differential Scanning Calorimetry (DSC), we studied the interaction between the DPPC and HSPC bilayers and MWCNTs. Liposome-MWCNTs delivery platforms prepared according to the protocol used in the literature. We used dynamic and electrophoretic light scattering in order to investigate the physicochemical characteristics of these mixed nanocarriers. The presence of MWCNTs causes alterations of the size of the conventional HSPC and DPPC liposomes. The ζ-potential values of mixed nanocarriers are near zero. This observation indicates the effective incorporation of MWCNTs into the lipid bilayer of liposomes. Fluorescence spectroscopy has been utilized to exact some qualitative information on the internal nanostructure and nanoenvironment of the lipid/carbon nanotube mixed structures. Finally, we conclude that we successfully prepare and completely characterize mixed nanocarriers composed of lipids and MWCNTs, with low toxicity as indicated by in vitro screening.
Τίτλος πηγής δημοσίευσης:	International Journal of Pharmaceutics
Τόμος/Κεφάλαιο:	528
Τεύχος:	1-2
Σελίδες:	429-439
Θεματική Κατηγορία:	[EL] Χημεία (Γενικά)[EN] Chemistry (General)
Λέξεις-Κλειδιά:	Liposomes Carbon nanotubes Drug delivery Nanocarriers Toxicity
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © Elsevier B.V.
Όροι και προϋποθέσεις δικαιωμάτων:	This is the author’s manuscript and appears in: “International Journal of Pharmaceutics, vol. 528, no. 1–2. Elsevier BV, 2017”. The definite version can be found at: https://doi.org/10.1016/j.ijpharm.2017.06.043
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S0378517317305513?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.elsevier.com/locate/ijpharm
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο