Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Bovine serum albumin interactions with cationic surfactant vesicles decorated by a low-molar-mass polysaccharide
Δημιουργός/Συγγραφέας:	[EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis
Εκδότης:	Elsevier B.V.
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	0927-7757
DOI:	10.1016/j.colsurfa.2017.10.058
Περίληψη:	The complexation of bovine serum albumin (BSA) with bare and sodium-hyaluronate (Na-HA)-modified didodecyldimethylammonium bromide (DDAB) vesicles is systematically investigated by static and dynamic light scattering in a broad range of scattering angles. The aggregation number of DDAB vesicles increases as a function of added Na-HA concentration because of the attractive interactions between the cationic surfactant and anionic polysaccharide that reduce the repulsions between the charged head groups of the surfactant. This is confirmed by the inversion of the vesicular surface charge upon addition of Na-HA. Interactions of BSA with DDAB vesicles are surprisingly found to be much stronger when Na-HA is adsorbed on the vesicles although in this case protein and vesicular surface charge are of the same sign. Apparently the anisotropically charged BSA globules are more effectively anchored on the complex interface of the Na-HA decorated DDAB vesicles in comparison to the uniform positively charged interface of bare DDAB vesicles. In addition the strong associations of the globular protein with the vesicles compromise the protein's secondary structure. This system can be a useful template for versatile nanocapsules with the ability to bind substances via hydrophobic and electrostatic interactions.
Τίτλος πηγής δημοσίευσης:	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Τόμος/Κεφάλαιο:	537
Σελίδες:	495-501
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Bovine serum albumin Complexation Didodecyldimethylammonium bromide Light scattering Sodium hyaluronate Vesicles
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 Elsevier B.V.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο