Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Tiny Rare-Earth Fluoride Nanoparticles Activate Tumour Cell Growth via Electrical Polar Interactions
Δημιουργός/Συγγραφέας:	Semashko V.V. Pudovkin M.S. [EL] Κεφαλάς, Αλκιβιάδης Κωνσταντίνος[EN] Cefalas, Alciviadis Constantinos Zelenikhin P.V. Gavriil V.E. Nizamutdinov A.S. [EL] Κόλλια, Ζωή[EN] Kollia, Zoe Ferraro A. [EL] Σαραντοπούλου, Ευαγγελία[EN] Sarantopoulou, Evangelia
Εκδότης:	Springer New York LLC
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	1931-7573
DOI:	10.1186/s11671-018-2775-z
Περίληψη:	Localised extracellular interactions between nanoparticles and transmembrane signal receptors may well activate cancer cell growth. Herein, tiny LaF3 and PrF3 nanoparticles in DMEM+FBS suspensions stimulated tumour cell growth in three different human cell lines (A549, SW837 and MCF7). Size distribution of nanoparticles, activation of AKT and ERK signalling pathways and viability tests pointed to mechanical stimulation of ligand adhesion binding sites of integrins and EGFR via a synergistic action of an ensemble of tiny size nanoparticles (< 10 nm). While tiny size nanoparticles may be well associated with the activation of EGFR, integrin interplay with nanoparticles remains a multifaceted issue. A theoretical motif shows that, within the requisite pN force scale, each ligand adhesion binding site can be activated by a tiny size dielectric nanoparticle via electrical dipole interaction. The size of the active nanoparticle stayed specified by the amount of the surface charges on the ligand adhesion binding site and the nanoparticle, and also by the separating distance between them. The polar component of the electrical dipole force remained inversely proportional to the second power of nanoparticle’s size, evincing that only tiny size dielectric nanoparticles might stimulate cancer cell growth via electrical dipole interactions. The work contributes towards recognising different cytoskeletal stressing modes of cancer cells.
Τίτλος πηγής δημοσίευσης:	Nanoscale Research Letters
Τόμος/Κεφάλαιο:	13
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Εφαρμοσμένη οπτική. Φωτονική[EN] Applied optics. Photonics
Λέξεις-Κλειδιά:	Atomic force microscopy Biosurfaces Cancer and nanoparticles EGFR Electrical dipole interactions Integrins Mechanosensors Mechanotransducers Nanotechnology Physics of cancer Tumorigenesis
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018, The Author(s).
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	European Commission, EC; Ministry of Education and Science of the Russian Federation, Minobrnauka: #02.A03.21.0002; General Secretariat for Research and Technology, GSRT: MIS 5002772; European Regional Development Fund, FEDER We acknowledge support by (I) The project “Advanced Materials and Devices” (MIS 5002409) which is implemented under the “Action for the Strategic Development on the Research and Technological Sector”, funded by the Operational Programme “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014-2020) and co-financed by Greece and the European Union (European Regional Development Fund). (II) The support project for Competitive Growth of Kazan Federal University, Russian Federation, Kazan Federal University (agreement #02.A03.21.0002).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο