Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	PLMA-b-POEGMA amphiphilic block copolymers as nanocarriers for the encapsulation of magnetic nanoparticles and indomethacin
Δημιουργός/Συγγραφέας:	Skandalis A. Sergides A. Bakandritsos A. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	MDPI
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	2073-4360
DOI:	10.3390/polym10010014
Περίληψη:	We report here on the utilization of poly(lauryl methacrylate)-b-poly(oligo ethylene glycol methacrylate) (PLMA-b-POEGMA) amphiphilic block copolymers, which form compound micelles in aqueous solutions, as nanocarriers for the encapsulation of either magnetic iron oxide nanoparticles or iron oxide nanoparticles, and the model hydrophobic drug indomethacin in the their hydrophobic core. The mixed nanostructures were characterized using dynamic light scattering (DLS) and transmission electron microscopy (TEM) in terms of their structure and solution properties. Magnetophoresis experiments showed that the mixed solutions maintain the magnetic properties of the initial iron oxide nanoparticles. Results indicate that the cumulative hydrophilic/hydrophobic balance of all components determines the colloidal stability of the nanosystems. The effect of salt and bovine serum albumin (BSA) protein concentration on the structure of the mixed nanostructures was also investigated. Disintegration of the mixed nanostructures was observed in both cases, showing the importance of these parameters in the structure formation and stability of such complex mixed nanosystems.
Τίτλος πηγής δημοσίευσης:	Polymers
Τόμος/Κεφάλαιο:	10
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Amphiphilic block copolymers Encapsulation Indomethacin Magnetic nanoparticles Micelles Self-assembly
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 by the author.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	CZ.1.05/2.1.00/19.0377, LO1305 Acknowledgments: The authors gratefully acknowledge support from the Ministry of Education, Youth and Sports of the Czech Republic (project LO1305 and CZ.1.05/2.1.00/19.0377) and Starska Jana for the transmission electron microscopy (TEM) facilities and TEM measurements respectively.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο