Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Self-assembly of poly(ethylene glycol-b-phenyl oxazoline) diblock copolymers in aqueous media and their interactions with proteins
Δημιουργός/Συγγραφέας:	Vlassi E. [EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	Springer Verlag
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	0303-402X
DOI:	10.1007/s00396-017-4076-y
Περίληψη:	Amphiphilic block copolymers composed of poly(ethylene glycol) (PEG) and poly(2-phenyl-2-oxazoline) (PPhOx) with different molecular weights and compositions are synthesized. Their molecular characteristics are determined by size exclusion chromatography (SEC), proton nuclear magnetic resonance (1H NMR), and Fourier transform infrared spectroscopy (FTIR). In aqueous solutions, the size of the formed aggregates is much higher than the one expected from single core-shell micelles and point to larger spherical aggregates as observed by light scattering. The aggregation state is found temperature-sensitive. The internal environment of these aggregates is considerably polar as evidenced by pyrene fluorescence measurements. The interactions of the synthesized diblock copolymers with fetal bovine serum (FBS) proteins are investigated, and further aggregation of the initial structures is observed in the presence of serum proteins. The ability of the PEG-b-PPhOx aggregates to associate with proteins is tested for the case of bovine serum albumin (BSA) where it is found that indeed accumulation of BSA globules occur because of hydrophobic interactions between the protein and the hydrophobic domains of the polymeric aggregates. [Figure not available: see fulltext.].
Τίτλος πηγής δημοσίευσης:	Colloid and Polymer Science
Τόμος/Κεφάλαιο:	295
Τεύχος:	8
Σελίδες:	1359-1369
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	Amphiphilic block copolymer Poly(2-phenyl-2-oxazoline) Protein complexation Self-assembled nanoparticles
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017, Springer-Verlag Berlin Heidelberg.
Σημειώσεις:	Partial financial support by the General Secretariat for Research and Technology, Greece, through project “Advanced Materials and Devices” (MIS: 5002409)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο