Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Physico-chemical Characterization and Basic Research Principles of Advanced Drug Delivery Nanosystems
Δημιουργός/Συγγραφέας:	Pippa N. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C.
Εκδότης:	wiley
Ημερομηνία:	2016
Γλώσσα:	Αγγλικά
ISBN:	9781119242628; 9781119242482
DOI:	10.1002/9781119242628.ch5
Περίληψη:	Pharmaceutical nanotechnology aims at the development of innovative medicines-based active pharmaceutical ingredients with nanosystems composed of intelligent bionanomaterials forming advanced drug delivery nanosystems (aDDnSs). Pharmaceutical industry follows the same path, investing in the bioactive molecule development in pharmaceutical nanotechnology. The physico- chemical characteristics of nanosystems (the formulation system) play a key role on administration, distribution, metabolism, and excretion (ADME profile) of the encapsulated drug. It should be noted that the minimum requirements of follow-on nanomedicine (nanosimilars) products are the highly similar physico- chemical characteristics (i.e. size, size distribution, Z-potential, etc.). In this chap- ter, the most important techniques including light scattering (dynamic, static, and electrophoretic), thermal analysis (especially differential scanning calorimetry), and imaging techniques are presented for the physico-chemical characterization of aDDnSs. These techniques are used extensively for the detailed characterization of aDDnSs, i.e. in the research and development of innovative nanocarriers, and are required from the regulatory authorities.
Τίτλος πηγής δημοσίευσης:	Intelligent Nanomaterials: Second Edition
Σελίδες:	107-125
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	drug delivery nanocarriers nanotechnology Physico-chemical characterization
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 Scrivener Publishing LLC. All rights reserved.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο