Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Polymer self-assembled nanostructures as innovative drug nanocarrier platforms
Δημιουργός/Συγγραφέας:	Pippa N. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C.
Εκδότης:	Bentham Science Publishers B.V.
Ημερομηνία:	2016
Γλώσσα:	Αγγλικά
ISSN:	1381-6128
DOI:	10.2174/1381612822666160217141232
Άλλο:	PubMed ID: 26898736
Περίληψη:	Background: Polymer self-assembled nanostructures are used in pharmaceutical sciences as bioactive molecules’ delivery systems for therapeutic and diagnostic purposes. Micelles, polyelectrolyte complexes, polymersomes, polymeric nanoparticles, nanogels and polymer grafted liposomes represent delivery vehicles that are marketed and/or under clinical development, as drug formulations. Methods: In this mini-review, these, recently appeared in the literature, innovative polymer drug nanocarrier platforms are discussed, starting from their technological development in the laboratory to their potential clinical use, through studies of their biophysics, thermodynamics, physical behavior, morphology, bio-mimicry, therapeutic efficacy and safety. The properties of an ideal drug delivery system are the structural control over size and shape of drug or imaging agent cargo/domain, biocompatibility, nontoxic polymer/ pendant functionality and the precise, nanoscale container and/or scaffolding properties with high drug or imaging agent capacity features. Self-assembled polymer nanostructures exhibit all these properties and could be considered as ideal drug nanocarriers through control of their size, structure and morphology, with the aid of a large variety of parameters, in vitro and in vivo. These modern trends reside at the interface of soft matter self-assembly and pharmaceutical sciences and the technologies for health. Conclusion: Great advantages related to basic science and applications are expected by understanding the self-assembly behavior of these polymeric nanotechnological drug delivery systems, created through bio-inspiration and biomimicry and have potential utilization into clinical applications.
Τίτλος πηγής δημοσίευσης:	Current Pharmaceutical Design
Τόμος/Κεφάλαιο:	22
Τεύχος:	19
Σελίδες:	2788-2795
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Drug delivery and targeting Nanocarrier platforms Nanogels Polyelectrolyte complexes Polymer grafted liposomes Polymeric micelles Polymeric nanoparticles Polymersomes
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2016 Bentham Science Publishers.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο