Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Kinetics of temperature response of PEO-b-PNIPAM-b-PAA triblock terpolymer aggregates and of their complexes with lysozyme
Δημιουργός/Συγγραφέας:	[EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis Meristoudi A. Hong K. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	Elsevier Ltd
Ημερομηνία:	2016
Γλώσσα:	Αγγλικά
ISSN:	0032-3861
DOI:	10.1016/j.polymer.2015.12.023
Περίληψη:	We present the kinetics of temperature response of a PEO-b-PNIPAM-b-PAA triblock terpolymer and of its complexes with lysozyme in aqueous solution. It is found that during the coil-to-globule transition of PNIPAM new bonds within the polymer aggregates are created, making the transition of the aggregates partially irreversible. This effect is also found for the protein loaded PEO-b-PNIPAM-b-PAA aggregates whereas in this case protein globules appear to enhance the formation of bonds, making the transition totally irreversible. The internal dynamics of both aggregates and complexes are "frozen" once the temperature is increased upon PINIPAM's LCST in water and remain so even when the temperature drops below LCST. We investigate the complexation kinetics of lysozyme and PEO-b-PNIPAM-b-PAA and observe that it occurs in two stages, one where protein globules adsorb on single pre-formed aggregates and one where protein globules cause inter-aggregate clustering.
Τίτλος πηγής δημοσίευσης:	Polymer
Τόμος/Κεφάλαιο:	83
Σελίδες:	111-115
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Kinetics Protein complexation Thermoresponsive polymers
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2015 Elsevier Ltd. All rights reserved.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Bronze, Green
Σημειώσεις:	European Commission, EC; European Social Fund, ESF Authors acknowledge financial support of the work by the NANOMACRO 1129 project which is implemented in the framework of the Operational Program “Education and Life-long Learning” (Action “ARISTEIA I”) and it is co-funded by the European Union ( European Social Fund ) and by national funds.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο