Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Imidazolium Quaternized Polymers Based On Poly(Chloromethyl Styrene) and their Complexes with FBS Proteins and DNA
Δημιουργός/Συγγραφέας:	Vlassi E. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	Wiley-VCH Verlag
Ημερομηνία:	2015
Γλώσσα:	Αγγλικά
ISSN:	1022-1352
DOI:	10.1002/macp.201500162
Περίληψη:	A novel series of imidazolium quaternized polymers based on poly(chloromethyl styrene) has been designed and synthesized, using nitroxide mediated polymerization and post-polymerization functionalization. They are characterized by ATR-FTIR (attenuated total reflectance-Fourier transform infrared spectra) and 1H NMR in terms of functional groups and composition, which indicate the success of the synthetic scheme utilized. The solution behavior of the quaternized polymers has been investigated in water, phosphate buffer saline (PBS), and PBS(90%)-FBS(10%) (fetal bovine serum) by static, dynamic, and electrophoretic light scattering. The functionalized polymers have been studied in terms of structure and stability during changes in temperature and ionic strength of their aqueous solutions. The copolymers form stable aggregates with positive surface charge. All cationic polymers are found to interact extensively with DNA via electrostatic interactions, forming stable complexes at certain ratios of the components. Amphiphilic polymers containing poly(chloromethyl styrene) segments have been synthesized by quaternization and characterized. The solution behavior of these polymers in aqueous and phosphate buffer saline media has been investigated. Also, their ability to complex with the proteins and the DNA chains is shown. These polyplexes are expected to have valuable implications for future utilization as drug nanocontainers.
Τίτλος πηγής δημοσίευσης:	Macromolecular Chemistry and Physics
Τόμος/Κεφάλαιο:	216
Τεύχος:	16
Σελίδες:	1718-1728
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	butylimidazole DNA complexes PCMS quaternization self-assembled nanoparticles
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο