Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Insulin/poly(ethylene glycol)- block -poly(l -lysine) complexes: Physicochemical properties and protein encapsulation
Δημιουργός/Συγγραφέας:	Pippa N. Kalinova R. Dimitrov I. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C.
Εκδότης:	American Chemical Society
Ημερομηνία:	2015
Γλώσσα:	Αγγλικά
ISSN:	1520-6106
DOI:	10.1021/acs.jpcb.5b01664
Άλλο:	PubMed ID: 25974620
Περίληψη:	Insulin (INS) was encapsulated into complexes with poly(ethylene glycol)-block-poly(l-lysine) (PEG-b-PLys), which is a polypeptide-based block copolymer (a neutral-cationic block polyelectrolyte). The particular cationic-neutral block copolymer can complex INS molecules in aqueous media via electrostatic interactions. Light-scattering techniques are used to study the complexation process and structure of the hybrid nanoparticles in a series of buffers, as a function of protein concentration. The physicochemical and structural characteristics of the complexes depend on the ionic strength of the aqueous medium, while the concentration of PEG-b-PLys was constant through the series of solutions. As INS concentration increased the size distribution of the complexes decreased, especially at the highest ionic strength. The size/structure of complexes diluted in biological medium indicated that the copolymer imparts stealth properties and colloidal and biological stability to the complexes, features that could in turn affect the clearance properties in vivo. Therefore, these studies could be a rational roadmap for designing the optimum complexes/effective nanocarriers for proteins and peptides.
Τίτλος πηγής δημοσίευσης:	Journal of Physical Chemistry B
Τόμος/Κεφάλαιο:	119
Τεύχος:	22
Σελίδες:	6813-6819
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2015 American Chemical Society.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Green
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο