Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Synthesis and self-assembly of thermoresponsive poly(N-isopropylacrylamide)-b-poly(oligo ethylene glycol methyl ether acrylate) double hydrophilic block copolymers
Δημιουργός/Συγγραφέας:	Giaouzi D. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	John Wiley and Sons Inc.
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	0887-624X
DOI:	10.1002/pola.29411
Περίληψη:	We report on the synthesis of novel poly(N-isopropylacrylamide)-b-poly(oligo ethylene glycol methyl ether acrylate) (PNIPAM-b-POEGA) thermoresponsive block copolymers using reversible addition–fragmentation chain transfer polymerization methodologies. The synthesized block copolymers are characterized by gel permeation chromatography, nuclear magnetic resonance, Fourier transform infrared (FTIR) techniques in terms of molecular weight and composition. Their thermoresponsive self-assembly in aqueous media is investigated using dynamic and static light scattering. The PNIPAM-b-POEGA thermoresponsive block copolymers formed aggregates in water by increasing the temperature above the lower critical solution temperature value of PNIPAM block. Solution pH seems to affect the self-assembly behavior in some cases due to the presence of COOH end groups. Therefore, the copolymers were utilized as “smart” nanocarries for the hydrophobic drug indomethacin, implementing a novel encapsulation protocol taking advantage of the thermoresponsive character of the PNIPAM block. The empty and loaded self-assembled nanocarriers systems were studied by light scattering techniques, ultraviolet–visible, and FTIR spectroscopy, which gave information on the size and structure of the nanocarriers, the drug loading content and the interactions between the drug and the components of the block copolymers. Drug loaded nanostructures show stability at room temperature, due to active drug/block copolymer interactions.
Τίτλος πηγής δημοσίευσης:	Journal of Polymer Science, Part A: Polymer Chemistry
Τόμος/Κεφάλαιο:	57
Τεύχος:	13
Σελίδες:	1467-1477
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	block copolymers encapsulation protocol nanocarriers RAFT polymerization self-assembly thermoresponsive
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 Wiley Periodicals, Inc.
Σημειώσεις:	Εθνικό 'Ίδρυμα Ερευνών Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 11635, Greece
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο