Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Bio-inspired chimeric drug delivery nano systems (Chi-DDnSs): Their fractal hologram and regulatory aspects
Δημιουργός/Συγγραφέας:	Pippa N. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C.
Εκδότης:	Springer New York LLC
Ημερομηνία:	2015
Γλώσσα:	Αγγλικά
ISSN:	0065-2598
DOI:	10.1007/978-3-319-08927-0_23
Άλλο:	PubMed ID: 25416991
Περίληψη:	Pharmaceutical Nanotechnology can provide challenges for producing innovative drugs based on bio-inspired nanostructures (advanced Drug Delivery nano Systems— aDDnSs) [1]. These systems could be correlated to the living organisms due to their self-assembly properties, their hierarchical structural organization, as well as to their biocompatibility and biodegradability characteristics. aDDnSs can be considered as new therapeutic outcomes in nanomedicine that may be able to deliver pharmacomolecules to specific tissues and can improve their PK/PD (pharmacokinetics/pharmacodynamics) behavior and affect their total bioavailability. Drug delivery is a scientific sector that promotes the innovation by designing formulation approaches that can produce aDDnSs. Drug nanocarriers produced by the combination of bionanomaterials, such as liposomes, (co)polymers and dendrimers, are considered as new classes of complex self-assembled soft nanostructures. The major advantage of such bio-inspired delivery systems lies in the ability to control the size, the structure, and the morphology of the nanoassembly, due to the cooperativity of the components. The morphology of nanoparticles has been recently described via fractal analysis [2-7]. The fractal dimension could be a useful tool for the development and characterization of innovative nanocarriers for pharmacomolecules with complete knowledge of their structural characteristics. This approach can disclose the pharmacokinetic reality of behavior of the candidate drugs, and can improve their therapeutic value by highlighting the interdependence of particle morphology and biological and pharmacokinetic processes. In conclusion, there is growing effort to refine methodologies for preparation and physicochemical characterization, in order for these new technologies to have the potential to meet regulatory requirements.
Τίτλος πηγής δημοσίευσης:	Advances in Experimental Medicine and Biology
Τόμος/Κεφάλαιο:	822
Σελίδες:	199-200
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© Springer International Publishing Switzerland 2015.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο