Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The shape/morphology balance: A study of stealth liposomes via fractal analysis and drug encapsulation
Δημιουργός/Συγγραφέας:	Pippa N. Psarommati F. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C.
Ημερομηνία:	2013
Γλώσσα:	Αγγλικά
ISSN:	0724-8741
DOI:	10.1007/s11095-013-1082-8
Άλλο:	PubMed ID: 23743657
Περίληψη:	Purpose: Fractal analysis was used as a tool in order to study the morphological characteristics of PEGylated liposomes. We report on the morphological characteristics of stealth liposomes composed of DPPC and DPPE-PEG 3000 in two dispersion media using fractal analysis. Methods: Light scattering techniques were used in order to elucidate the size, the morphology and the surface charge of PEGylated liposomes as a function of PEGylated lipid concentration and temperature. Fluorescence spectroscopy studies revealed a microenvironment of low polarity inside the liposomal membranes. Results: All formulations were found to retain their physicochemical characteristics for at least 3 weeks. The hydrodynamic radii (Rh) of stealth liposomes were stable in the process of heating up to 50 C; while the fractal dimension values (df) which correspond to their morphology, have been changed during heating. Hence, these results are a first indication of the presence of a heterogeneous microdomain structure of the stealth liposomal system. The amphiphilic drug indomethacin (IND) was successfully encapsulated within the liposomes and led to an increased size of stealth liposomes, while the morphology of liposomal vectors changed significantly at the highest molar ratio of PEGylated lipid. Conclusions: We can state that this approach can promote a new analytical concept based on the morphological characteristics and quantify the shape of drug carriers complementary to that of the conventional analytical techniques.
Τίτλος πηγής δημοσίευσης:	Pharmaceutical Research
Τόμος/Κεφάλαιο:	30
Τεύχος:	9
Σελίδες:	2385-2395
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	fractal dimension indomethacin morphology pegylated nanoparticles shape
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2013 Springer Science+Business Media New York.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο