Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Quaternized poly[3,5-bis(dimethylaminomethylene)hydroxystyrene]/DNA complexes: Structure formation as a function of solution ionic strength
Δημιουργός/Συγγραφέας:	Delisavva F. Mountrichas G. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	American Chemical Society
Ημερομηνία:	2013
Γλώσσα:	Αγγλικά
ISSN:	1520-6106
DOI:	10.1021/jp402525s
Περίληψη:	The formation of complexes between the cationic polyelectrolyte poly[3,5-bis(dimethylaminomethylene)hydroxystyrene] (Q-N-PHOS), bearing two cationic sites per repeating unit, and DNA molecules in aqueous solutions is investigated at pH 7 and at various salt (NaCl) concentrations and DNA/polymer ratios. The structural characteristics of the polyplexes at different DNA/polymer ratios were characterized in terms of mass, size, and charge using static, dynamic, and electrophoretic light scattering and fluorescence spectroscopy. The results indicate that the complexes have a loose spherical morphology with size in the range of 45-100 nm depending on polymer to DNA ratio and ionic strength of the solution. Most interestingly, it is found that the polyplexes' response to changes in the ionic strength of the surrounding solution after complexation depends strongly on the initial solution ionic strength during complex formation. This also points to differences in the nanostructures of polyplexes formed at different ionic strengths.
Τίτλος πηγής δημοσίευσης:	Journal of Physical Chemistry B
Τόμος/Κεφάλαιο:	117
Τεύχος:	25
Σελίδες:	7790-7796
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2013 American Chemical Society.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο