Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	DPPC:MPOx chimeric advanced Drug Delivery nano Systems (chi-aDDnSs): Physicochemical and structural characterization, stability and drug release studies
Δημιουργός/Συγγραφέας:	Pippa N. Merkouraki M. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C.
Ημερομηνία:	2013
Γλώσσα:	Αγγλικά
ISSN:	0378-5173
DOI:	10.1016/j.ijpharm.2013.03.052
Άλλο:	PubMed ID: 23618959
Περίληψη:	Chimeric advanced Drug Delivery nano Systems (chi-aDDnSs) could be defined as mixed nanosystems composed of different biomaterials that can be organized into new nanostructures that can offer advantages as drug carriers. In this work, we report on the self assembly behavior and on stability studies of chi-aDDnSs consisting of DPPC (dipalmitoylphosphatidylcholine) and poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) (MPOx) gradient copolymer in Phosphate Buffer Saline (PBS). Light scattering techniques were used in order to extract information on their physicochemical and structural characteristics (i.e. ζ-potential, Polydispersity Index (PD.I.), size/shape and morphology), while their stability was also studied as a function of gradient block copolymer content, as well as temperature. The colloidal stability of the chimeric nanovectors and their thermoresponsive behavior indicates that these nanosystems could be considered as sterically stabilized nanocontainers. DPPC:MPOx chimeric advanced Drug Delivery nano Systems were found to be effective nanocontainers for the incorporation of indomethacin (IND). The combination of gradient block copolymers with phospholipids for the development of novel chimeric nanovectors is reported for the first time and appears very promising, mostly due to the fact that the MPOx acts as a modulator for the release rate of the IND.
Τίτλος πηγής δημοσίευσης:	International Journal of Pharmaceutics
Τόμος/Κεφάλαιο:	450
Τεύχος:	1-2
Σελίδες:	1-10
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Chimeric aDDnSs Drug release Fractal dimension Gradient block copolymer Polymersomes Self-assembly
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2013 Elsevier B.V.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο