Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Incorporation of dimethoxycurcumin into charged liposomes and the formation kinetics of fractal aggregates of uncharged vectors
Δημιουργός/Συγγραφέας:	Hadjidemetriou M. Pippa N. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C.
Ημερομηνία:	2013
Γλώσσα:	Αγγλικά
ISSN:	0898-2104
DOI:	10.3109/08982104.2012.747534
Άλλο:	PubMed ID: 23294394
Περίληψη:	Dimethoxycurcumin (DMC) is a lipophilic analog of curcumin found in Curcuma longa Linn., which is known to possess significant activity against various cancer cell lines. The purpose of this study was to develop suitable liposomal formulations in order to overcome DMC's poor water solubility and to study the aggregation kinetic profile using the fractal analysis. DMC was incorporated into liposomal formulations composed of DPPC, DPPC:DPPG:chol (9:1:1 molar ratio) and DPPC:DODAP:chol (9:1:1 molar ratio) liposomes. Light scattering techniques were used to elucidate the physicochemical parameters of the liposomal formulations with and without DMC. The structural characteristics of the incorporated molecule were found to be crucial and promote the aggregation mechanism depending also on the liposomes' composition. The results of our study contribute to the overall scientific efforts to prepare efficient carriers for DMC and could be a useful tool in order to study more efficiently the kinetics of the aggregation process of the liposomal carriers.
Τίτλος πηγής δημοσίευσης:	Journal of Liposome Research
Τόμος/Κεφάλαιο:	23
Τεύχος:	2
Σελίδες:	94-100
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Aggregation kinetics Colloidal stability Dimethoxycurcumin Extended DLVO theory Fractal dimension
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2013 Informa UK Ltd All rights reserved.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο