Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	DPPC/poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) chimeric nanostructures as potential drug nanocarriers
Δημιουργός/Συγγραφέας:	Pippa N. Kaditi E. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C.
Εκδότης:	Kluwer Academic Publishers
Ημερομηνία:	2013
Γλώσσα:	Αγγλικά
ISSN:	1388-0764
DOI:	10.1007/s11051-013-1685-3
Περίληψη:	In this study, we report on the self assembly behavior and on stability studies of mixed (chimeric) nanosystems consisting of dipalmitoylphosphatidylcholine (DPPC) and poly(2-methyl-2-oxazoline)-grad- poly(2-phenyl-2-oxazoline) (MPOx) gradient copolymer in aqueous media and in fetal bovine serum (FBS). A gamut of light scattering techniques and fluorescence spectroscopy were used in order to extract information on the size and morphological characteristics of the nanoassemblies formed, as a function of gradient block copolymer content, as well as temperature. The hydrodynamic radii (R h) of nanoassemblies decreased in the process of heating up to 50 C, while the fractal dimension (d f) values, also increased. Indomethacin was successfully incorporated into these chimeric nanocarriers. Drug release was depended on the components ratio. The present studies show that there are a number of parameters that can be used in order to alter the properties of chimeric nanosystems, and this is advantageous to the development of "smart" nanocarriers for drug delivery.
Τίτλος πηγής δημοσίευσης:	Journal of Nanoparticle Research
Τόμος/Κεφάλαιο:	15
Τεύχος:	6
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	Chimeric nanocarriers Fractal dimension Gradient block copolymer Morphology Self-assembly Stealth nanocarriers
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2013 Springer Science+Business Media Dordrecht.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο