Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Sulforaphane - role in aging and neurodegeneration
Δημιουργός/Συγγραφέας:	Santín-Márquez R. Alarcón-Aguilar A. López-Diazguerrero N.E. [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Königsberg M.
Εκδότης:	Springer
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	2509-2715
DOI:	10.1007/s11357-019-00061-7
Άλλο:	PubMed ID: 30941620
Περίληψη:	In the last several years, numerous molecules derived from plants and vegetables have been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables. SFN activates the antioxidant and anti-inflammatory responses by inducing Nrf2 pathway and inhibiting NF-κB. It also has an epigenetic effect by inhibiting HDAC and DNA methyltransferases and modifies mitochondrial dynamics. Moreover, SFN preserves proteome homeostasis (proteostasis) by activating the proteasome, which has been shown to lead to increased cellular lifespan and prevent neurodegeneration. In this review, we describe some of the molecular and physical characteristics of SFN, its mechanisms of action, and the effects that SFN treatment induces in order to discuss its relevance as a “miraculous” drug to prevent aging and neurodegeneration.
Τίτλος πηγής δημοσίευσης:	GeroScience
Τόμος/Κεφάλαιο:	41
Τεύχος:	5
Σελίδες:	655-670
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	HDAC NF-κB Nrf2 Oxidative stress Proteasome
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2019, American Aging Association.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Green
Σημειώσεις:	MIS 5002398, T1EDK-00353, T1EDK-01610; Consejo Nacional de Ciencia y Tecnología, CONACYT: FON.INST/298/2016. This work was supported by CONACyT grant FON.INST/298/2016, as well as the “Red Temática de Investigación en Salud y Desarrollo Social” from CONACYT, Mexico. Santín-Márquez is a CONACyT scholarship holder. Research from NC lab is currently co-financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, (a) under the call RESEARCH – CREATE – INNOVATE (project code: T1EDK-00353 and T1EDK-01610) and (b) under the Action “Action for the Strategic Development on the Research and Technological Sector” (project STHENOS-b, MIS 5002398).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο