Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study
Δημιουργός/Συγγραφέας:	Pinchuk I. Weber D. Kochlik B. Stuetz W. Toussaint O. Debacq-Chainiaux F. Dollé M.E.T. Jansen E.H.J.M. [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Sikora E. Breusing N. Gradinaru D. Sindlinger T. Moreno-Villanueva M. Bürkle A. Grune T. Lichtenberg D.
Εκδότης:	Elsevier B.V.
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	2213-2317
DOI:	10.1016/j.redox.2019.101204
Άλλο:	PubMed ID: 31022674
Περίληψη:	Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers of OS in 2207 healthy individuals of the cross-sectional MARK-AGE Project. The correlations among biomarkers were significant but weak. These findings may indicate different manifestations of OS and must further be evaluated. Here, we report a refined analysis of OS based on the above-mentioned original data. We show that malondialdehyde (MDA) appears to be sensitive to both gender and age. It is significantly lower and shows a greater age-dependence in women than in men. The age-dependency of MDA in women arises in a stepwise fashion. The age-dependent slope of the steady state concentration is maximal at the age between 50 and 55 years, indicating that it may be attributed to the change of metabolism in the post-menopause. Interestingly, total glutathione (GSH) decreased with age simultaneously with the increase in MDA. Different biomarkers yield different gender- and age-dependencies. Unlike the concentration of MDA, the concentrations of the other two oxidation products, i.e. protein carbonyls and 3-nitrotyrosine were similar in men and women and appeared to be independent of age in the healthy study population. The analyzed antioxidants exhibited different gender- and age-dependencies. In conclusion, it appears that all the biomarkers assessed here reflect different types of OS and that MDA and GSH reflect the same type of OS.
Τίτλος πηγής δημοσίευσης:	Redox Biology
Τόμος/Κεφάλαιο:	24
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Age-dependency Biomarkers Gender-associated differences Oxidative stress
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 The Authors
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	200880; European Commission, EC. Financial support through the European Union's 7th Framework Programme Research and Innovation funding 2014-2020 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; Grant Agreement no. 200880 ).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο