Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents
Δημιουργός/Συγγραφέας:	Mitsiogianni M. Koutsidis G. Mavroudis N. Trafalis D.T. Botaitis S. Franco R. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis Amery T. Galanis A. Pappa A. Panayiotidis M.I.
Εκδότης:	MDPI
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	2076-3921
DOI:	10.3390/antiox8040106
Περίληψη:	Many studies have shown evidence in support of the beneficial effects of hytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.
Τίτλος πηγής δημοσίευσης:	Antioxidants
Τόμος/Κεφάλαιο:	8
Τεύχος:	4
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens)
Λέξεις-Κλειδιά:	Cell cycle Chemo-therapy Cruciferous vegetables Glucosinolates Growth arrest Isothiocyanates Malignant melanoma Skin cancer
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 by the authors.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	Support from Northumbria University at Newcastle, UK and specifically the Multidisciplinary Research Theme (MDRT) in Bio-economy (MP & MM).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο