Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer
Δημιουργός/Συγγραφέας:	Vlahopoulos S. Adamaki M. Khoury N. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis Boldogh I.
Εκδότης:	Elsevier Inc.
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	0163-7258
DOI:	10.1016/j.pharmthera.2018.09.004
Άλλο:	PubMed ID: 30240635
Περίληψη:	Cytokines are pivotal mediators of the immune response, and their coordinated expression protects host tissue from excessive damage and oxidant stress. Nevertheless, the development of lung pathology, including asthma, chronic obstructive pulmonary disease, and ozone-induced lung injury, is associated with oxidant stress; as evidence, there is a significant increase in levels of the modified guanine base 7,8-dihydro-8-oxoguanine (8-oxoG) in the genome. 8-OxoG is primarily recognized by 8-oxoguanine glycosylase 1 (OGG1), which catalyzes the first step in the DNA base excision repair pathway. However, oxidant stress in the cell transiently halts enzymatic activity of substrate-bound OGG1. The stalled OGG1 facilitates DNA binding of transactivators, including NF-κB, to their cognate sites to enable expression of cytokines and chemokines, with ensuing recruitments of inflammatory cells. Hence, defective OGG1 will modulate the coordination between innate and adaptive immunity through excessive oxidant stress and cytokine dysregulation. Both oxidant stress and cytokine dysregulation constitute key elements of oncogenesis by KRAS, which is mechanistically coupled to OGG1. Thus, analysis of the mechanism by which OGG1 modulates gene expression helps discern between beneficial and detrimental effects of oxidant stress, exposes a missing functional link as a marker, and yields a novel target for lung cancer.
Τίτλος πηγής δημοσίευσης:	Pharmacology and Therapeutics
Τόμος/Κεφάλαιο:	194
Σελίδες:	59-72
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Innate immune response Kirsten-Ras Lung cancer Metastasis OGG1 Reactive oxygen species
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 Elsevier Inc.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Green
Σημειώσεις:	National Institute of Allergy and Infectious Diseases, NIAID: P01AI062885; National Institute of Environmental Health Sciences, NIEHS: P30ES006676, R01ES018948. This work was in part supported by Grants from the United States National Institute of Environmental Health Sciences (Grant number: RO1 ES018948 to IB); P30 ES006676 (IB); and United States National Institute of Allergy and Infectious Diseases (Grant number: AI062885, to IB). This work was in part supported by Grants from the United States National Institute of Environmental Health Sciences (Grant number: RO1 ES018948 to IB); P30 ES006676 (IB); and United States National Institute of Allergy and Infectious Diseases (Grant number: AI062885 , to IB).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο