Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Proteasome modulation: A way to delay aging?
Δημιουργός/Συγγραφέας:	[EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Vasilopoulou M.A. Kapetanou M. [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.
Εκδότης:	Elsevier
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISBN:	9780128160763; 9780128160756
DOI:	10.1016/B978-0-12-801238-3.11461-8
Περίληψη:	The ability to maintain a functional proteome, or proteostasis, is challenged as aging progresses. Misfolded and damaged proteins accumulate with age, causing perturbations to cellular and tissue function that hallmarks a multitude of age-related diseases. The proteasome is one of the main cellular protein clearance mechanisms, is a key component of the proteostasis network and has a crucial role in cellular physiology. Proteasome function exhibits an age-related decline that has been correlated with the accumulation of protein aggregates and the progression of proteotoxic disorders. Strategies that may promote proteasome expression, assembly, or activity extend both cellular and organismal lifespan and delay the progression of late-onset pathologies. In this review, we discuss the links between proteasome dysfunction and aging as well as the different approaches that can induce proteasome expression/assembly/activity/function and their potential to decelerate aging and degenerative diseases.
Τίτλος πηγής δημοσίευσης:	Encyclopedia of Biomedical Gerontology
Σελίδες:	92-104
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Aging Caenorhabditis elegans Cellular senescence Drosophila melanogaster Longevity Proteasome Proteasome activation Proteostasis Saccharomyces cerevisiae Ubiquitin-proteasome system
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 Elsevier Inc. All rights reserved.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο