Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Impact of antioxidant natural compounds on the thyroid gland and implication of the Keap1/Nrf2 signaling pathway
Δημιουργός/Συγγραφέας:	Paunkov A. Chartoumpekis D.V. Ziros P.G. [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Kensler T.W. Sykiotis G.P.
Εκδότης:	Bentham Science Publishers
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	1381-6128
DOI:	10.2174/1381612825666190701165821
Άλλο:	PubMed ID: 31267862
Περίληψη:	Background: Natural compounds with potential antioxidant properties have been used in the form of food supplements or extracts with the intent to prevent or treat various diseases. Many of these compounds can activate the cytoprotective Nrf2 pathway. Besides, some of them are known to impact the thyroid gland, often with potential side-effects, but in other instances, with potential utility in the treatment of thyroid disorders. Objective: In view of recent data regarding the multiple roles of Nrf2 in the thyroid, this review summarizes the current bibliography on natural compounds that can have an effect on thyroid gland physiology and pathophysiology, and it discusses the potential implication of the Nrf2 system in the respective mechanisms. Methods & Results: Literature searches for articles from 1950 to 2018 were performed in PubMed and Google Scholar using relevant keywords about phytochemicals, Nrf2 and thyroid. Natural substances were categorized into phenolic compounds, sulfur-containing compounds, quinones, terpenoids, or under the general category of plant extracts. For individual compounds in each category, respective data were summarized, as derived from in vitro (cell lines), preclinical (animal models) and clinical studies. The main emerging themes were as follows: phenolic compounds often showed potential to affect the production of thyroid hormones; sulfur-containing compounds impacted the pathogenesis of goiter and the proliferation of thyroid cancer cells; while quinones and terpenoids modified Nrf2 signaling in thyroid cell lines. Conclusion: Natural compounds that modify the activity of the Nrf2 pathway should be evaluated carefully, not only for their potential to be used as therapeutic agents for thyroid disorders, but also for their thyroidal safety when used for the prevention and treatment of non-thyroidal diseases.
Τίτλος πηγής δημοσίευσης:	Current Pharmaceutical Design
Τόμος/Κεφάλαιο:	25
Τεύχος:	16
Σελίδες:	1828-1846
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Flavonoid Goiter Hyperthyroidism Hypothyroidism Nrf2 Personalized nutrition Phytochemical Thyroid
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 Bentham Science Publishers
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Green
Σημειώσεις:	CA16112; IZ-COZ0_177070; 174626 - C15.0045; European Cooperation in Science and Technology, COST; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, SNF: 31003A_153062, 31003A_182105; Fondation Leenaards; Staatssekretariat für Bildung, Forschung und Innovation, SBFI. This work was supported by the Swiss National Science Foundation Research Grants 31003A_153062 and 31003A_182105; Leenaards Foundation 2016 Fellowship for Academic Promotion in Clinical Medicine; Swiss National Science Foundation - State Secretariat for Education, Research and Innovation (SNF-COST) Project 174626 - C15.0045; and SNF COST Project IZ-COZ0_177070 (all to GPS). This work was supported by the Swiss National Science Foundation Research Grants 31003A_153062 and 31003A_182105; Leenaards Foundation 2016 Fellowship for Academic Promotion in Clinical Medicine; Swiss National Science Foundation - State Secretariat for Education, Research and Innovation (SNF-COST) Project 174626 - C15.0045; and SNF COST Project IZCOZ0_177070 (all to GPS). The work benefited from COST Action CA16112 (NutRedOx), supported by European Cooperation in Science and Technology (COST) (participants: DVC, NC, GPS), including a Short-Term Scientific Mission (to DVC).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο