Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Anomeric spironucleosides of β-D-glucopyranosyl uracil as potential inhibitors of glycogen phosphorylase
Δημιουργός/Συγγραφέας:	Stathi A. Mamais M. [EL] Χρυσίνα, Ευαγγελία Δ.[EN] Chrysina, Evangelia D. Gimisis T.
Εκδότης:	MDPI AG
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	1420-3049
DOI:	10.3390/molecules24122327
Άλλο:	PubMed ID: 31242546
Περίληψη:	In the case of type 2 diabetes, inhibitors of glycogen phosphorylase (GP) may prevent unwanted glycogenolysis under high glucose conditions and thus aim at the reduction of excessive glucose production by the liver. Anomeric spironucleosides, such as hydantocidin, present a rich synthetic chemistry and important biological function (e.g., inhibition of GP). For this study, the Suárez radical methodology was successfully applied to synthesize the first example of a 1,6-dioxa-4-azaspiro[4.5]decane system, not previously constructed via a radical pathway, starting from 6-hydroxymethyl-β-d-glucopyranosyluracil. It was shown that, in the rigid pyranosyl conformation, the required [1,5]-radical translocation was a minor process. The stereochemistry of the spirocycles obtained was unequivocally determined based on the chemical shifts of key sugar protons in the 1H-NMR spectra. The two spirocycles were found to be modest inhibitors of RMGPb.
Τίτλος πηγής δημοσίευσης:	Molecules
Τόμος/Κεφάλαιο:	24
Τεύχος:	12
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Χημεία (Γενικά)[EN] Chemistry (General)
Λέξεις-Κλειδιά:	1,6-dioxa-4-azaspiro[4.5]decane Anomeric spironucleosides Glycogen phosphorylase Type 2 diabetes [1,5]-radical translocation
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 by the authors.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο