Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	UHPLC–HRMS-based tissue untargeted metabolomics study of naringin and hesperidin after dietary supplementation in chickens
Δημιουργός/Συγγραφέας:	Baira E. Dagla I. [EL] Σιάπη, Ελένη[EN] Siapi, Eleni [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis Simitzis P. Goliomytis M. Deligeorgis S.G. Skaltsounis A.-L. Gikas E.
Εκδότης:	Elsevier Ltd
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	0308-8146
DOI:	10.1016/j.foodchem.2018.06.146
Άλλο:	PubMed ID: 30100435
Περίληψη:	To date numerous metabolomic studies have been performed in order to characterize nutritional intervention studies. The aim of the current study was to present a comprehensive pipeline for characterizing the metabolic changes that occur in chickens tissues in response to naringin and hesperidin dietary supplementation. Forty-nine chickens were randomly divided into 3 groups: the first one fed with diet supplemented with naringin, the second with hesperidin whereas the control group was fed by commercial basal diet. After 30 days of administration chicken muscle samples were analyzed by UHPLC–HRMS whereas data were analyzed by the proposed pipeline. Three significant variables were detected to discriminate the control from the group after naringin administration and thirteen variables after hesperidin supplementation. Furthermore, a more detailed pipeline (encompassing multiple internal standards, internal validation of the clustering, extended statistical significance scores and multiple identification procedures) has been proposed aiming towards a more accurate untargeted analysis.
Τίτλος πηγής δημοσίευσης:	Food Chemistry
Τόμος/Κεφάλαιο:	269
Σελίδες:	276-285
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Metabolomics MVA Normalization Online databases R statistical language Software tools
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο