Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses
Δημιουργός/Συγγραφέας:	Vermeulen R. Saberi Hosnijeh F. Bodinier B. Portengen L. Liquet B. Garrido-Manriquez J. Lokhorst H. Bergdahl I.A. [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Johansson A.-S. [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis Melin B. Palli D. Krogh V. Panico S. Sacerdote C. Tumino R. Vineis P. Castagné R. Chadeau-Hyam M. Botsivali M. [EL] Χατζηιωάννου, Αριστοτέλης[EN] Chatziioannou, Aristotelis Valavanis I. Kleinjans J.C.S. de Kok T.M.C.M. Keun H.C. Athersuch T.J. Kelly R. Lenner P. Hallmans G. Stephanou E.G. Myridakis A. Kogevinas M. Fazzo L. De Santis M. Comba P. Bendinelli B. Kiviranta H. Rantakokko P. Airaksinen R. Ruokojarvi P. Gilthorpe M. Fleming S. Fleming T. Tu Y.-K. Lundh T. Chien K.-L. Chen W.J. Lee W.-C. Kate Hsiao C. Kuo P.-H. Hung H. Liao S.-F. on behalf of the EnviroGenoMarkers Consortium Consortium members
Εκδότης:	Wiley-Liss Inc.
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	0020-7136
DOI:	10.1002/ijc.31536
Άλλο:	PubMed ID: 29667176
Περίληψη:	Recent prospective studies have shown that dysregulation of the immune system may precede the development of B-cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to a few immune markers, which were considered separately. Using a nested case–control study within two European prospective cohorts, we measured plasma levels of 28 immune markers in samples collected a median of 6 years before diagnosis (range 2.01–15.97) in 268 incident cases of BCL (including multiple myeloma [MM]) and matched controls. Linear mixed models and partial least square analyses were used to analyze the association between levels of immune marker and the incidence of BCL and its main histological subtypes and to investigate potential biomarkers predictive of the time to diagnosis. Linear mixed model analyses identified associations linking lower levels of fibroblast growth factor-2 (FGF-2 p = 7.2 × 10−4) and transforming growth factor alpha (TGF-α, p = 6.5 × 10−5) and BCL incidence. Analyses stratified by histological subtypes identified inverse associations for MM subtype including FGF-2 (p = 7.8 × 10−7), TGF-α (p = 4.08 × 10−5), fractalkine (p = 1.12 × 10−3), monocyte chemotactic protein-3 (p = 1.36 × 10−4), macrophage inflammatory protein 1-alpha (p = 4.6 × 10−4) and vascular endothelial growth factor (p = 4.23 × 10−5). Our results also provided marginal support for already reported associations between chemokines and diffuse large BCL (DLBCL) and cytokines and chronic lymphocytic leukemia (CLL). Case-only analyses showed that Granulocyte-macrophage colony stimulating factor levels were consistently higher closer to diagnosis, which provides further evidence of its role in tumor progression. In conclusion, our study suggests a role of growth-factors in the incidence of MM and of chemokine and cytokine regulation in DLBCL and CLL.
Τίτλος πηγής δημοσίευσης:	International Journal of Cancer
Τόμος/Κεφάλαιο:	143
Τεύχος:	6
Σελίδες:	1335-1347
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	cytokine lymphoma mixed-effect modeling multiple myeloma multivariate models prospective cohort time to diagnosis
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Hybrid Gold, Green
Σημειώσεις:	Seventh Framework Programme, FP7: 226756; Fondation pour la recherche juridique, FRJ; Universiteit Utrecht, UU: 22184; Fondation pour la Recherche Médicale, FRM: SPE20120523823; Seventh Framework Programme, FP7
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο