Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights
Δημιουργός/Συγγραφέας:	Cheimonidi C. Samara P. Polychronopoulos P. Tsakiri E.N. Nikou T. Myrianthopoulos V. Sakellaropoulos T. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis Mikros E. Papassideri I. Argyropoulou A. Halabalaki M. Alexopoulos L.G. Skaltsounis A.-L. Tsitsilonis O.E. Aligiannis N.N. [EL] Τρουγκάκος, Ιωάννης Π.[EN] Trougakos, Ioannis P.
Εκδότης:	Elsevier B.V.
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	2213-2317
DOI:	10.1016/j.redox.2018.02.015
Άλλο:	PubMed ID: 29505920
Περίληψη:	Natural products are characterized by extreme structural diversity and thus they offer a unique source for the identification of novel anti-tumor agents. Herein, we report that the herbal substance acteoside being isolated by advanced phytochemical methods from Lippia citriodora leaves showed enhanced cytotoxicity against metastatic tumor cells; acted in synergy with various cytotoxic agents and it sensitized chemoresistant cancer cells. Acteoside was not toxic in physiological cellular contexts, while it increased oxidative load, affected the activity of proteostatic modules and suppressed matrix metalloproteinases in tumor cell lines. Intraperitoneal or oral (via drinking water) administration of acteoside in a melanoma mouse model upregulated antioxidant responses in the tumors; yet, only intraperitoneal delivery suppressed tumor growth and induced anti-tumor-reactive immune responses. Mass-spectrometry identification/quantitation analyses revealed that intraperitoneal delivery of acteoside resulted in significantly higher, vs. oral administration, concentration of the compound in the plasma and tumors of treated mice, suggesting that its in vivo anti-tumor effect depends on the route of administration and the achieved concentration in the tumor. Finally, molecular modeling studies and enzymatic activity assays showed that acteoside inhibits protein kinase C. Conclusively, acteoside holds promise as a chemical scaffold for the development of novel anti-tumor agents.
Τίτλος πηγής δημοσίευσης:	Redox Biology
Τόμος/Κεφάλαιο:	16
Σελίδες:	169-178
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Acteoside Cancer Immunomodulation Natural compound Oxidative stress Proteostasis
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 The Authors
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	General Secretariat for Research and Technology, GSRT: EnGAGE 11ΣΥΝ-1-420
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο