Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study
Δημιουργός/Συγγραφέας:	Weinberger B. Keller M. Putzer C. Breitenberger D. Koller B. Fiegl S. Moreno-Villanueva M. Bernhardt J. Franceschi C. [EL] Βουτετάκης, Κωνσταντίνος[EN] Voutetakis, Konstantinos [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Hurme M. Sikora E. Toussaint O. Debacq-Chainiaux F. Grune T. Breusing N. Bürkle A. Grubeck-Loebenstein B.
Εκδότης:	Elsevier Inc.
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	0531-5565
DOI:	10.1016/j.exger.2017.08.037
Άλλο:	PubMed ID: 29017961
Περίληψη:	Due to the successful implementation of vaccination strategies early-life morbidity and mortality due to infectious disease has been reduced dramatically. Vaccines against tetanus and diphtheria are among the most frequently used vaccines worldwide, but various studies in different European countries have shown that protection against tetanus and particularly against diphtheria is unsatisfactory in adults and older persons. In this study we analyzed tetanus- and diphtheria-specific antibody concentrations in 2100 adults of different age from 6 selected European countries (Austria, Belgium, Germany, Greece, Italy, Poland) in order to investigate differences in the level of protection against tetanus and diphtheria across Europe. Our data reveal that tetanus- and diphtheria-specific antibody concentrations vary greatly between countries, which is also reflected in the percentage of persons with antibody concentrations below the protective level (0.1 IU/ml), which ranged from 2 to 31% percent for tetanus and 28–63% for diphtheria. In most countries, tetanus- and diphtheria-specific antibody concentrations decrease with age. This phenomenon is more pronounced in countries with generally low antibody levels, such as Italy, Poland and Greece. Interestingly, tetanus-specific antibody concentrations are generally higher in males than in females, which is probably due to vaccination during their military service or more frequent booster vaccinations after injuries, whereas no gender-related differences were found for diphtheria-specific antibodies. In conclusion, our study demonstrates that the European population is not fully protected against tetanus and diphtheria. Measures to improve protection should include a life-long perspective on vaccination, more education to increase awareness of and compliance with vaccination guidelines, and a harmonization of recommendations and incentives across Europe.
Τίτλος πηγής δημοσίευσης:	Experimental Gerontology
Τόμος/Κεφάλαιο:	105
Σελίδες:	109-112
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Antibody concentrations Diphtheria Europe Tetanus Vaccination
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 Elsevier Inc.
Σημειώσεις:	Seventh Framework Programme, FP7; European Commission, EC; Seventh Framework Programme, FP7: 200880. Financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880 ). This work was supported by the European Union's Seventh Framework Program , project MARK-AGE (European study to establish biomarkers of human ageing, grant agreement no. 200880).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο