Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Ultraestructural study of effects of alkylphospholipid analogs against nematodes
Δημιουργός/Συγγραφέας:	Sant'Anna V. Railbolt M. Oliveira-Menezes A. [EL] Καλογεροπούλου, Θεοδώρα[EN] Calogeropoulou, Theodora Pinheiro J. de Souza W.
Εκδότης:	Academic Press Inc.
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	0014-4894
DOI:	10.1016/j.exppara.2018.02.004
Άλλο:	PubMed ID: 29496523
Περίληψη:	Alkylphospholipid analogs were initially developed as anticancer agents and were later found to antiparasitic activity. Miltefosine is the prototype alkylphosphocholine and is the first oral treatment against visceral leishmaniasis. Here we investigated the effects of miltefosine and two ring-substituted alkylphosphocholine derivatives, TCAN26 and TC70, on the viability, morphology, and ultrastructure of the life stages of Caenorhabditis elegans and infective larvae of the parasite Strongyloides venezuelensis. Miltefosine displayed activity against C. elegans adults at low concentrations and was more effective than TCAN26 and TC70. Miltefosine inhibited the hatching of eggs, leading to embryonic lethality, and showed larvicidal activity against C. elegans and S. venezuelensis larvae after 24 h. Mitelfosine also induced alterations in the reproductive system of hermaphrodites, causing vulvar prolapse and general effects in the body wall. Electron microscopy analysis showed that miltefosine induced selective embryonic lethality, leading to cell death. Our results suggest that alkylphospholipid analogs are a potential new alternative for anti-nematode chemotherapy.
Τίτλος πηγής δημοσίευσης:	Experimental Parasitology
Τόμος/Κεφάλαιο:	187
Σελίδες:	49-58
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Anthelmintic Miltefosine Morphology Ultrastructure
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 Elsevier Inc.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Bronze
Σημειώσεις:	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, FAPERJ
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο