Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Perspectives from the NanoSafety Modelling Cluster on the validation criteria for (Q)SAR models used in nanotechnology
Δημιουργός/Συγγραφέας:	Puzyn T. Jeliazkova N. Sarimveis H. Marchese Robinson R.L. Lobaskin V. Rallo R. Richarz A.-N. Gajewicz A. [EL] Παπαδόπουλος, Μάνθος Γ.[EN] Papadopoulos, Manthos G. Hastings J. Cronin M.T.D. Benfenati E. Fernández A.
Εκδότης:	Elsevier Ltd
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	0278-6915
DOI:	10.1016/j.fct.2017.09.037
Άλλο:	PubMed ID: 28943385
Περίληψη:	Nanotechnology and the production of nanomaterials have been expanding rapidly in recent years. Since many types of engineered nanoparticles are suspected to be toxic to living organisms and to have a negative impact on the environment, the process of designing new nanoparticles and their applications must be accompanied by a thorough risk analysis. (Quantitative) Structure-Activity Relationship ([Q]SAR) modelling creates promising options among the available methods for the risk assessment. These in silico models can be used to predict a variety of properties, including the toxicity of newly designed nanoparticles. However, (Q)SAR models must be appropriately validated to ensure the clarity, consistency and reliability of predictions. This paper is a joint initiative from recently completed European research projects focused on developing (Q)SAR methodology for nanomaterials. The aim was to interpret and expand the guidance for the well-known “OECD Principles for the Validation, for Regulatory Purposes, of (Q)SAR Models”, with reference to nano-(Q)SAR, and present our opinions on the criteria to be fulfilled for models developed for nanoparticles.
Τίτλος πηγής δημοσίευσης:	Food and Chemical Toxicology
Τόμος/Κεφάλαιο:	112
Σελίδες:	7
Θεματική Κατηγορία:	[EL] Τεχνολογία (Γενικά)[EN] Technology (General)
Λέξεις-Κλειδιά:	Nano-QSAR QNAR QNTR QSAR Validation
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 Elsevier Ltd
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Green
Σημειώσεις:	310465, 604134, FP7-NMP-2013-SMALL-7; Seventh Framework Programme, FP7: 309837; Agence Nationale de la Recherche, ANR; Fundacja na rzecz Nauki Polskiej, FNP: 309314; Generalitat de Catalunya: 2014 SGR 1352; Seventh Framework Programme, FP7. Funding received from the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement n° 309837 (NanoPUZZLES project) and TP and AG acknowledge the financial support of the Foundation for Polish Science (FOCUS Programme). Funding received from the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 309314 (MODERN project) and from the Generalitat de Catalunya (2014 SGR 1352 ). Funding received by the European Union's Seventh Framework Programme for research, technological development and demonstration (FP7-NMP-2013-SMALL-7) under grant agreement no. 604134 (eNanoMapper project). Funding received from the European Union Seventh Framework Programme under grant agreement n° 310465 (MembraneNanoPart project). TP, RLMR, ANR, AG, MGP, MTDC and EB acknowledge the funding received from the European Union Seventh Framework Programme (FP7/2007?2013) under grant agreement n? 309837 (NanoPUZZLES project) and TP and AG acknowledge the financial support of the Foundation for Polish Science (FOCUS Programme). RR and AF acknowledge the funding received from the European Union Seventh Framework Programme (FP7/2007?2013) under grant agreement no. 309314 (MODERN project) and from the Generalitat de Catalunya (2014 SGR 1352). NJ, JH and HS acknowledge the funding received by the European Union's Seventh Framework Programme for research, technological development and demonstration (FP7-NMP-2013-SMALL-7) under grant agreement no. 604134 (eNanoMapper project). VL acknowledges the funding received from the European Union Seventh Framework Programme under grant agreement n? 310465 (MembraneNanoPart project).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο