Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Microbial genetic screens for monitoring protein misfolding associated with neurodegeneration: Tools for identifying disease-relevant genes and for screening synthetic and natural compound libraries for the discovery of potential therapeutics
Δημιουργός/Συγγραφέας:	Kostelidou K. Matis I. [EL] Σκρέτας, Γιώργος[EN] Skretas, George
Εκδότης:	Bentham Science Publishers B.V.
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	1381-6128
DOI:	10.2174/1381612824666180515143752
Άλλο:	PubMed ID: 29766788
Περίληψη:	Neurodegenerative Diseases (ND) are a major threat to the aging population and the lack of a single preventive or disease-modifying agent only serves to increase their impact. In the past few years, protein misfolding and the subsequent formation of neurotoxic oligomeric/aggregated protein species have emerged as a unifying theme underlying the pathology of these complex diseases. Recently developed microbial genetic screens and selection systems for monitoring ND-associated protein misfolding have allowed the establishment of high-throughput assays for the identification of cellular factors and processes that are important mediators of ND-associated proteotoxicities. In addition, such systems have facilitated the discovery of synthetic and natural compounds with the ability to rescue the misfolding and the associated pathogenic effects of aggregation-prone proteins associated with NDs. This review outlines such available systems in bacteria and yeast, whose usage will likely accelerate the pre-clinical discovery process for effective drugs against a variety of NDs with high socioeconomic impact.
Τίτλος πηγής δημοσίευσης:	Current Pharmaceutical Design
Τόμος/Κεφάλαιο:	24
Τεύχος:	19
Σελίδες:	1
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	High-throughput Microbial genetic screening Neurodegenerative diseases Polyphenolic natural products Protein aggregation Protein misfolding
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 Bentham Science Publishers.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο