Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Social adversity and epigenetic aging: A multi-cohort study on socioeconomic differences in peripheral blood DNA methylation
Δημιουργός/Συγγραφέας:	Fiorito G. Polidoro S. Dugué P.-A. Kivimaki M. Ponzi E. Matullo G. Guarrera S. Assumma M.B. [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Krogh V. Palli D. Panico S. Sacerdote C. Tumino R. Chadeau-Hyam M. Stringhini S. Severi G. Hodge A.M. Giles G.G. Marioni R. Karlsson Linnér R. O'Halloran A.M. Kenny R.A. Layte R. Baglietto L. Robinson O. McCrory C. Milne R.L. Vineis P.
Εκδότης:	Nature Publishing Group
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	2045-2322
DOI:	10.1038/s41598-017-16391-5
Άλλο:	PubMed ID: 29176660
Περίληψη:	Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.
Τίτλος πηγής δημοσίευσης:	Scientific Reports
Τόμος/Κεφάλαιο:	7
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 The Author(s).
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	1026522, 1026892, 1050198, 1074383, 209057, 623206; K013351; National Science Foundation, NSF: 1011618, 1043616; Compagnia di San Paolo; Horizon 2020 Framework Programme, H2020: 633666; Seventh Framework Programme, FP7: 226756; Medical Research Council, MRC: MR/K013351/1, MR/M501669/1; European Commission, EC; Trinity College Dublin, TCD; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, SNF: PZ00P3_147998; NordForsk
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο