Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Δημιουργός/Συγγραφέας:	Egea J. Fabregat I. Frapart Y.M. Ghezzi P. Görlach A. Kietzmann T. Kubaichuk K. Knaus U.G. Lopez M.G. Olaso-Gonzalez G. Petry A. Schulz R. Vina J. Winyard P. Abbas K. Ademowo O.S. Afonso C.B. Andreadou I. Antelmann H. Antunes F. Aslan M. Bachschmid M.M. Barbosa R.M. Belousov V. Berndt C. Bernlohr D. Bertrán E. Bindoli A. Bottari S.P. Brito P.M. Carrara G. Casas A.I. Chatzi A. [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Conrad M. Cooke M.S. Costa J.G. Cuadrado A. My-Chan Dang P. De Smet B. Debelec-Butuner B. Dias I.H.K. Dunn J.D. Edson A.J. El Assar M. El-Benna J. Ferdinandy P. Fernandes A.S. Fladmark K.E. Förstermann U. Giniatullin R. Giricz Z. Görbe A. Griffiths H. Hampl V. Hanf A. Herget J. Hernansanz-Agustín P. Hillion M. Huang J. Ilikay S. Jansen-Dürr P. Jaquet V. Joles J.A. Kalyanaraman B. Kaminskyy D. Karbaschi M. Kleanthous M. Klotz L.-O. Korac B. Korkmaz K.S. Koziel R. Kračun D. Krause K.-H. Křen V. Krieg T. Laranjinha J. Lazou A. Li H. Martínez-Ruiz A. Matsui R. McBean G.J. Meredith S.P. Messens J. Miguel V. Mikhed Y. Milisav I. Milković L. Miranda-Vizuete A. Mojović M. Monsalve M. Mouthuy P.-A. Mulvey J. Münzel T. Muzykantov V. Nguyen I.T.N. Oelze M. Oliveira N.G. Palmeira C.M. Papaevgeniou N. Pavićević A. Pedre B. Peyrot F. Phylactides M. Pircalabioru G.G. Pitt A.R. Poulsen H.E. Prieto I. Rigobello M.P. Robledinos-Antón N. Rodríguez-Mañas L. Rolo A.P. Rousset F. Ruskovska T. Saraiva N. Sasson S. Schröder K. Semen K. Seredenina T. Shakirzyanova A. Smith G.L. Soldati T. Sousa B.C. Spickett C.M. Stancic A. Stasia M.J. Steinbrenner H. Stepanić V. Steven S. Tokatlidis K. Tuncay E. Turan B. Ursini F. Vacek J. Vajnerova O. Valentová K. Van Breusegem F. Varisli L. Veal E.A. Yalçın A.S. Yelisyeyeva O. Žarković N. Zatloukalová M. Zielonka J. Touyz R.M. Papapetropoulos A. Grune T. Lamas S. Schmidt H.H.H.W. Di Lisa F. Daiber A.
Εκδότης:	Elsevier B.V.
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	2213-2317
DOI:	10.1016/j.redox.2017.05.007
Άλλο:	PubMed ID: 28577489
Περίληψη:	The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.
Τίτλος πηγής δημοσίευσης:	Redox Biology
Τόμος/Κεφάλαιο:	13
Σελίδες:	94-162
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Χημεία (Γενικά)[EN] Chemistry (General)
Λέξεις-Κλειδιά:	Antioxidants Oxidative stress Reactive nitrogen species Reactive oxygen species Redox signaling Redox therapeutics
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 The Authors
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK: R01DK103750; Horizon 2020 Framework Programme, H2020: 669026, 675132; Medical Research Council, MRC: G0900224; Deutsche Forschungsgemeinschaft, DFG: 198215150
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο