| Περίληψη: | Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent, heterogeneous decline of physiological functions, aging is orchestrated by a plethora of molecular mechanisms, which vividly interact to alter body homeostasis. The ability of an organism to adjust to these alterations, in conjunction with the dynamic effect of various environmental stimuli across lifespan, promotes longevity, frailty or disease. Endocrine function undergoes major changes during aging, as well. Specifically, alterations in hormonal networks and concomitant hormonal deficits/excess, augmented by poor sensitivity of tissues to their action, take place. As hypothalamic-pituitary unit is the central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae that can impair the quality of life and promote frailty and disease. Delineating the hormonal signaling alterations that occur across lifespan and exploring possible remedial interventions could possibly help us improve the quality of life of the elderly and promote longevity. |
| Σημειώσεις: | Texas A and M University-Central Texas; Aristotle University of Thessaloniki; Agricultural University of Athens; Hellenic Foundation for Research and Innovation.
1Department of Endocrinology, Diabetes and Metabolic Diseases, Euroclinic Hospital, Athens, Greece, 2Parthenogen, Lugano, Switzerland, 3Clinic for Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia, 4Medical School, University of Ulm, Ulm, Germany, 5Endocrine Clinic, Evgenidion Hospital, University of Athens, Athens, Greece, 6National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece, 7First Department of Obstetrics & Gynecology, Medical School, Aristotle University of Thessaloniki, Unit of Reproductive Endocrinology, Thessaloniki, Greece, 8First Department of Pediatrics Medical School, Aghia Sophia Children’s Hospital, National and Kapodistrian University of Athens, Athens, Greece, 9Endocrine Department, Elena Venizelou Hospital, Athens, Greece, 102nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece, 11Endocrine Division, Internal Medicine Department, University Hospital of Patras, Patras, Greece, 12Department of Internal Medicine, Mc Goven Medical School, The University of Texas, Houston, Texas, USA, 13S. Orsola-Malpighi Hospital of Bologna, Bologna, Italy, 14Second Department of Internal Medicine Propaedeutic, Research Institute and Diabetes Center, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece, 15Evangelismos Hospital, Athens, Greece, 16Endocrine Unit, 2nd Department of Internal Medicine, Attikon University Hospital, Athens, Greece, and 17Department of Endocrinology, Diabetes and Metabolism, ‘Red Cross Hospital’, Athens, Greece |
