Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Epigenetic memory in response to environmental stressors
Δημιουργός/Συγγραφέας:	Vineis P. [EL] Χατζηιωάννου, Αριστοτέλης[EN] Chatziioannou, Aristotelis Cunliffe V.T. Flanagan J.M. Hanson M. Kirsch-Volders M. [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A.
Εκδότης:	FASEB
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	0892-6638
DOI:	10.1096/fj.201601059RR
Άλλο:	PubMed ID: 28280003
Περίληψη:	Exposure to environmental stressors, toxicants, and nutrient deficiencies can affect DNA in severalways. Someexposures causedamage and alter the structure of DNA, but there is increasing evidence that the same or other environmental exposures, including those that occur during fetal development in utero, can cause epigenetic effects thatmodulate DNA function and gene expression. Some epigenetic changes to DNA that affect gene transcription are at least partially reversible (i.e., they can be enzymatically reversed after cessation of exposure to environmental agents), but some epigenetic modifications seem to persist, even for decades. To explain the effects of early life experiences (such as famine and exposures to other stressors) on the long-term persistence of specific patterns of epigenetic modifications, such as DNA methylation, we propose ananalogy with immunememory. We propose that an epigenetic memory can be established and maintained in self-renewing stemcell compartments. We suggest that the observations on early life effects on adult diseases and the persistence of methylation changes in smokers support our hypothesis, for which a mechanistic basis, however, needs to be further clarified. We outline a new model based on methylation changes. Although these changes seemto bemainly adaptive, they are also implicated in the pathogenesis and onset of diseases, depending on individual genotypic background and types of subsequent exposures. Elucidating the relationships between the adaptive and maladaptive consequences of the epigenetic modifications that result fromcomplex environmental exposures is amajor challenge for current andfuture research in epigenetics.
Τίτλος πηγής δημοσίευσης:	FASEB Journal
Τόμος/Κεφάλαιο:	31
Τεύχος:	6
Σελίδες:	2241-2251
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	DNA methylation Environmental exposures Genes
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© FASEB.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Green
Σημειώσεις:	Horizon 2020 Framework Programme, H2020: 633666; Seventh Framework Programme, FP7: 308610; Economic and Social Research Council, ESRC: ES/N000528/1; National Institute for Health Research, NIHR; Cancer Research UK, CRUK; University of Southampton; Imperial College London; Imperial College Healthcare NHS Trust; Seventh Framework Programme, FP7; Horizon 2020. This work was supported by the Enhanced Exposure Assessment and Omic Profiling for High Priority Environmental Exposures in Europe (EXPOSOMICS) funded by EC FP7 Grant 308610, and by the European Union's Horizon 2020 Research and Innovation Programme (Grant 633666 to P.V.). Support from Cancer Research UK (CRUK) Centres, the Experimental Cancer Medicine Centre (ECMC), and the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust, Imperial College London, and at University of Southampton.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο