Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Carbon nanohorn/liposome systems: Preformulation, design and in vitro toxicity studies
Δημιουργός/Συγγραφέας:	Pippa N. Stangel C. Kastanas I. Triantafyllopoulou E. Naziris N. [EL] Στέλλας, Δημήτρης[EN] Stellas, Dimitris Zhang M. Yudasaka M. Demetzos C. [EL] Ταγματάρχης, Νίκος[EN] Tagmatarchis, Nikos
Εκδότης:	Elsevier Ltd
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	0928-4931
DOI:	10.1016/j.msec.2019.110114
Άλλο:	PubMed ID: 31546408
Περίληψη:	In the present work, the convergence of two different drug delivery systems is investigated, namely the combination of carbon nanohorns (CNHs) and liposomes. Our effort initially included the synthesis of two conversely charged carbon nanohorns and their subsequent analysis through various methods. The study of their effect on the thermotropic behavior of artificial membranes provided an essential assistance for the upcoming liposome preparation, which were estimated for their physicochemical properties. The presence of CNHs alters the calorimetric parameters of the lipids. We also prepared CNHs:liposome systems. The characteristic morphology and secondary spherical superstructure of CNHs is retained in the chimeric materials, suggesting that the interactions with the liposomes do not alter the dahlia-flower-like aggregation of CNHs. Both CNHs-liposome systems exhibit a relatively small cellular cytotoxicity in vitro, tested in mouse embryonic fibroblasts. To summarize, we developed CNHs:liposome platforms with a complete knowledge of their thermotropic, physicochemical, morphological and nanotoxicological characteristics.
Τίτλος πηγής δημοσίευσης:	Materials Science and Engineering C
Τόμος/Κεφάλαιο:	105
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Carbon nanohorns Differential scanning calorimetry Liposomes TEM Toxicity
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 Elsevier B.V.
Σημειώσεις:	European Commission, EC; Japan Society for the Promotion of Science, KAKEN: 17H02742; European Regional Development Fund, FEDER Partial support of this work by the project “Advanced Materials and Devices” (MIS 5002409) which is implemented under the “Action for the Strategic Development on the Research and Technological Sector”, funded by the Operational Program “Competitiveness, Entrepreneurship and Innovation” ( NSRF 2014-2020) and co-financed by Greece ( Ministry of Economy and Development ) and the European Union ( European Regional Development Fund ) is acknowledged.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο