Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases
Δημιουργός/Συγγραφέας:	[EL] Χατζηιωάννου, Αριστοτέλης[EN] Chatziioannou, Aristotelis [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis Hebels D.G. Liampa I. Valavanis I. Bergdahl I.A. Johansson A. Palli D. Chadeau-Hyam M. Siskos A.P. Keun H. Botsivali M. De Kok T.M.C.M. Pérez A.E. Kleinjans J.C.S. Vineis P. [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Gottschalk R. Van Leeuwen D. Timmermans L. Bendinelli B. Kelly R. Vermeulen R. Portengen L. Saberi-Hosnijeh F. Melin B. Hallmans G. Lenner P. Athersuch T.J. Kogevinas M. Stephanou E.G. Myridakis A. Fazzo L. De Santis M. Comba P. Kiviranta H. Rantakokko P. Airaksinen R. Ruokojarvi P. Gilthorpe M. Fleming S. Fleming T. Tu Y.-K. Jonsson B. Lundh T. Chen W.J. Lee W.-C. Hsiao C.K. Chien K.-L. Kuo P.-H. Hung H. Liao S.-F.
Εκδότης:	Nature Publishing Group
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	2045-2322
DOI:	10.1038/srep42870
Άλλο:	PubMed ID: 28225026
Περίληψη:	We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.
Τίτλος πηγής δημοσίευσης:	Scientific Reports
Τόμος/Κεφάλαιο:	7
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Ιατρική (Γενικά)[EN] Medicine (General)
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s) 2017.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο