Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound
Δημιουργός/Συγγραφέας:	Filippopoulou K. Papaevgeniou N. Lefaki M. Paraskevopoulou A. Biedermann D. Křen V. [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki
Εκδότης:	Elsevier Inc.
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	0891-5849
DOI:	10.1016/j.freeradbiomed.2016.12.042
Άλλο:	PubMed ID: 28039083
Περίληψη:	Aging is an unavoidable process characterized by gradual failure of homeostasis that constitutes a critical risk factor for several age-related disorders. It has been unveiled that manipulation of various key pathways may decelerate the aging progression and the triggering of age-related diseases. As a consequence, the identification of compounds, preferably natural-occurring, administered through diet, with lifespan-extending, anti-aggregation and anti-oxidation properties that in parallel exhibit negligible side-effects is the main goal in the battle against aging. Here we analyze the role of 2,3-dehydrosilybin A/B (DHS A/B), a minor component of silymarin used in a plethora of dietary supplements. This flavonolignan is well-known for its anti-oxidative and neuroprotective properties, among others. We demonstrate that DHS A/B confers oxidative stress resistance not only in human primary cells but also in the context of a multi-cellular aging model, namely Caenorhabditis elegans (C. elegans) where it also promotes lifespan extension. We reveal that these DHS A/B outcomes are FGT-1 and DAF-16 dependent. We additionally demonstrate the anti-aggregation properties of DHS A/B in human cells of nervous origin but also in nematode models of Alzheimer's disease (AD), eventually leading to decelerated progression of AD phenotype. Our results identify DHS A/B as the active component of silymarin extract and propose DHS A/B as a candidate anti-aging and anti-aggregation compound.
Τίτλος πηγής δημοσίευσης:	Free Radical Biology and Medicine
Τόμος/Κεφάλαιο:	103
Σελίδες:	256-267
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	2,3-dehydrosilybin A/B Anti-aggregation Anti-aging Anti-oxidation DAF-16 FGT-1
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 Elsevier Inc.
Σημειώσεις:	National Center for Research Resources, NCRR: 3.7.12 MIS380228; European Commission, EC; European Cooperation in Science and Technology, COST; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT: LD15081; European Social Fund, ESF
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο