Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The indispensable contribution of s38 protein to ovarian-eggshell morphogenesis in Drosophila melanogaster
Δημιουργός/Συγγραφέας:	Velentzas A.D. Velentzas P.D. Katarachia S.A. Anagnostopoulos A.K. Sagioglou N.E. Thanou E.V. Tsioka M.M. Mpakou V.E. [EL] Κόλλια, Ζωή[EN] Kollia, Zoe Gavriil V.E. Papassideri I.S. Tsangaris G.T. [EL] Κεφαλάς, Αλκιβιάδης Κωνσταντίνος[EN] Cefalas, Alciviadis Constantinos [EL] Σαραντοπούλου, Ευαγγελία[EN] Sarantopoulou, Evangelia Stravopodis D.J.
Εκδότης:	Nature Publishing Group
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	2045-2322
DOI:	10.1038/s41598-018-34532-2
Άλλο:	PubMed ID: 30382186
Περίληψη:	Drosophila chorion represents a remarkable model system for the in vivo study of complex extracellular-matrix architectures. For its organization and structure, s38 protein is considered as a component of major importance, since it is synthesized and secreted during early choriogenesis. However, there is no evidence that proves its essential, or redundant, role in chorion biogenesis. Hence, we show that targeted downregulation of s38 protein, specifically in the ovarian follicle-cell compartment, via employment of an RNAi-mediated strategy, causes generation of diverse dysmorphic phenotypes, regarding eggshell’s regionally and radially specialized structures. Downregulation of s38 protein severely impairs fly’s fertility and is unable to be compensated by the s36 homologous family member, thus unveiling s38 protein’s essential contribution to chorion’s assembly and function. Altogether, s38 acts as a key skeletal protein being critically implicated in the patterning establishment of a highly structured tripartite endochorion. Furthermore, it seems that s38 loss may sensitize choriogenesis to stochastic variation in its coordination and timing.
Τίτλος πηγής δημοσίευσης:	Scientific Reports
Τόμος/Κεφάλαιο:	8
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018, The Author(s).
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	?Section of Cell Biology and Biophysics, Department of Biology, School of Science, National and Kapodistrian University of Athens (NKUA), Athens, Greece. ?Systems Biology Center, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece. ?Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation (NHRF), Athens, Greece.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο