Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Homeobox gene involvement in normal hematopoiesis and in the pathogenesis of childhood Leukemias
Δημιουργός/Συγγραφέας:	Adamaki, Maria Goulielmaki M. Christodoulou I. Vlahopoulos S. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis
Εκδότης:	Begell House Inc.
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	0893-9675
DOI:	10.1615/CritRevOncog.2017024465
Άλλο:	PubMed ID: 29604897
Περίληψη:	Homeobox (HOX) genes are a superfamily of highly conserved genes with essential functions in many aspects of mammalian development. Their expression is tightly regulated throughout the duration of definitive hematopoiesis, so the pathogenetic mechanism that leads to leukemia suggests that malignant transformation is directly intertwined with the deregulation of HOX gene expression. Even though HOX gene involvement has been reviewed extensively in adult leukemias, childhood leukemias have received much less attention and mainly in the context of leukemias harboring MLL (mixed-lineage leukemia) gene translocations. In recent years, scientific evidence has highlighted HOX gene involvement in the development of other subtypes of childhood leukemias and added HOX gene family members that were previously unrelated to the pathogenesis of childhood leukemia. This has significant implications when considering both the risk stratification of pediatric patients and potential targets for successful therapy. Through the identification of HOX target genes, their resulting interactions, and the cognate signaling pathways, we hope to gain a better understanding of the molecular mechanism(s) underlying the ectopic activation of these genes in childhood leukemias and subsequently to reveal new molecular targets for successful therapy in cases of poor prognosis or resistant disease.
Τίτλος πηγής δημοσίευσης:	Critical Reviews in Oncogenesis
Τόμος/Κεφάλαιο:	22
Τεύχος:	3-4
Σελίδες:	157-185
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	CDX Hematopoiesis Homeobox Leukemogenesis LincRNAs MiR-196 MLL NKL TALE
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 by Begell House, Inc.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο