Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	New: N -(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents
Δημιουργός/Συγγραφέας:	Incerti M. Vicini P. Geronikaki A. Eleftheriou P. Tsagkadouras A. [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis Fotakis C. Ćirić A. Glamočlija J. Soković M.
Εκδότης:	Royal Society of Chemistry
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	2040-2503
DOI:	10.1039/c7md00334j
Περίληψη:	A series of 21 novel N-[2-phenyl-4-oxo-1,3-thiazolidin-3-yl]-1,2-benzothiazole-3-carboxamides/acetamides (4a-4p) as well as a series of N′-(halophenylmethylidene)-1,2-benzothiazole-3-acetohydrazides (3h-3p) have been synthesized and evaluated for their antimicrobial activity against eight bacterial and eight fungal species, among them plant, animal and human pathogens and food contaminating species. All compounds appeared to be potent and the best activity was exhibited by compound 4d with MIC in the range of 10.7-21.4 μmol mL-1 × 10-2 and MBC of 21.4-40.2 μmol mL-1 × 10-2. The best antifungal activity was observed for compounds 4p and 3h. Elucidation of the relationship between the antimicrobial activity and molecular properties of the synthesized compounds was also performed. Synthetic intermediates were also tested with several exhibiting good antimicrobial activities. Docking studies for some compounds were performed.
Τίτλος πηγής δημοσίευσης:	MedChemComm
Τόμος/Κεφάλαιο:	8
Τεύχος:	11
Σελίδες:	2142-2154
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Βιοχημεία[EN] Biochemistry
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 The Royal Society of Chemistry.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Green
Σημειώσεις:	aDipartimento di Scienze degli Alimenti e del Farmaco, Universita' degli Studi di Parma, Italy bAristotle University, School of Pharmacy, Thessaloniki, 54124, Greece. E-mail: geronik@pharm.auth.gr; Fax: +302310 998559; Tel: +30 2310 997616 cDepartment of Medical Laboratory Studies, School of Health and Medical Care, Alexander Technological Educational Institute of Thessaloniki, Greece dInstitute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vas. Constantinou Ave., 11635, Athens, Greece eMycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković, University of Belgrade, Bulevar, Serbia.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο