Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	MiRNAs and their role in the correlation between schizophrenia and cancer (Review)
Δημιουργός/Συγγραφέας:	Rizos E. Siafakas N. Skourti E. Papageorgiou C. Tsoporis J. Parker T.H. Christodoulou D.I. [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A. Katsantoni E. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis
Εκδότης:	Spandidos Publications
Ημερομηνία:	2016
Γλώσσα:	Αγγλικά
ISSN:	1791-2997
DOI:	10.3892/mmr.2016.5853
Άλλο:	PubMed ID: 27748930
Περίληψη:	Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is conversely characterized by an increase in appropriate molecular signaling that stimulates uncontrolled cell proliferation. The rather low risk of developing Ca in patients suffering from SZ is a hypothesis that is still under debate. Recent evidence has indicated that microRNAs (miRNAs or miRs), a large group of small non-coding oligonoucleotides, may play a significant role in the development of Ca and major psychiatric disorders, such as SZ, bipolar disorder, autism spectrum disorders, suicidality and depression, through their interference with the expression of multiple genes. For instance, the possible role of let-7, miR-98 and miR-183 as biomarkers for Ca and SZ was investigated in our previous research studies. Therefore, further investigations on the expression profiles of these regulatory, small RNA molecules and the molecular pathways through which they exert their control may provide a plausible explanation as to whether there is a correlation between psychiatric disorders and low risk of developing C.a.
Τίτλος πηγής δημοσίευσης:	Molecular Medicine Reports
Τόμος/Κεφάλαιο:	14
Τεύχος:	6
Σελίδες:	4942-4946
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Cancer MicroRNA Schizophrenia
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Hybrid Gold, Green
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο