Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Prenatal exposure to persistent organic pollutants in association with offspring neuropsychological development at 4 years of age: The Rhea mother-child cohort, Crete, Greece
Δημιουργός/Συγγραφέας:	Kyriklaki A. Vafeiadi M. Kampouri M. Koutra K. Roumeliotaki T. Chalkiadaki G. Anousaki D. Rantakokko P. Kiviranta H. Fthenou E. Bitsios P. [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Kogevinas M. Chatzi L.
Εκδότης:	Elsevier Ltd
Ημερομηνία:	2016
Γλώσσα:	Αγγλικά
ISSN:	0160-4120
DOI:	10.1016/j.envint.2016.09.012
Άλλο:	PubMed ID: 27666324
Περίληψη:	Background Persistent Organic Pollutants (POPs) are highly-resistant compounds to environmental degradation and due to fat solubility they bioaccumulate through the food chain. As they cross the placenta, in utero exposure to POPs could disrupt child neurodevelopment as they are considered to be neurotoxic. Aims We examined whether in utero exposure to levels of different POPs is associated with offspring cognitive and behavioral outcomes at 4 years of age in a mother-child cohort in Crete, Greece (Rhea study). Methods We included 689 mother-child pairs. Concentrations of several polychlorinated biphenyls (PCBs) and other organochlorine compounds (dichlorodiphenyl dichloroethene [DDE], hexachlorobenzene [HCB]) were determined in maternal serum collected in the first trimester of pregnancy by triple quadrupole mass spectrometry. Neurodevelopment at 4 years was assessed by means of the McCarthy Scales of Children's Abilities. Behavioral difficulties were assessed by Strengths and Difficulties Questionnaire and Attention Deficit Hyperactivity Disorder Test. Linear regression analyses were used to estimate the associations between the exposures and outcomes of interest after adjustment for potential confounders. Results Children with “high” HCB concentrations (≥ 90th percentile) in maternal serum, demonstrated decreased scores in perceptual performance (adjusted β = − 6.07; 95% CI: − 10.17, − 1.97), general cognitive (adjusted β = − 4.97; 95% CI: − 8.99, − 0.96), executive function (adjusted β = − 6.24; 95% CI: − 10.36, − 2.11) and working memory (adjusted β = − 4.71; 95% CI: − 9.05, − 0.36) scales at 4 years of age. High exposure to PCBs (≥ 90th percentile) during pregnancy was associated with a 4.62 points reduction in working memory score at 4 years of age (95% CI: − 9.10, − 0.14). Prenatal exposure to DDE, HCB and PCBs was not associated with child behavioral difficulties. Conclusions The findings suggest that prenatal exposure to HCB and PCBs may contribute to reduced cognitive development at preschool age. Our results raise the possibility that exposure to HCB may play a more important role in child cognition than previously considered.
Τίτλος πηγής δημοσίευσης:	Environment International
Τόμος/Κεφάλαιο:	97
Σελίδες:	204-211
Θεματική Κατηγορία:	[EL] Τοξικολογία[EN] Toxicology. Poisons
Λέξεις-Κλειδιά:	Cognition HCB McCarthy Scales for Children's Abilities Neuropsychological development PCBs Persistent organic pollutants
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2016 Elsevier Ltd
Σημειώσεις:	264357; 2012-15; Sixth Framework Programme, FP6: 226285, 308333 HELIX. The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EUFP7- HEALTH-2012 Proposal No 308333 HELIX), MeDALL (FP7 European Union project, No. 264357), and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο